Merck, 03-0199-00, SMC® Human NPTX2 High Sensitivity Immunoassay Kit

General description
Neuronal Pentraxin 2 (NPTX2) actively contributes to synaptic function and plasticity in the brain. As a member of the pentraxin family, NPTX2 regulates synaptic transmission and clears excess neurotransmitters. Predominantly expressed in neurons, it facilitates the formation and maintenance of synapses, playing a crucial role in learning and memory. NPTX2 has been linked to conditions such as Alzheimer′s disease and schizophrenia. Altered levels of NPTX2 correlate with synaptic dysfunction and cognitive decline, suggesting its potential as a biomarker for these diseases. Additionally, NPTX2 influences neuroinflammatory processes by affecting interactions between neurons and glial cells. Understanding NPTX2′s function and its impact on synaptic integrity and neuroinflammation is essential for developing therapeutic strategies that aim to preserve cognitive function and mitigate the effects of neurodegeneration in various neurological disorders.
Application
NeuroscienceNeurological DisordersNeuronal & Glial Markers
Features and Benefits
Ultrasensitive Detection: Detects NPTX2 at femtogram per milliliter levels in serum, plasma and CSF.
Improved Signal Fidelity: Expanded dynamic range and higher signal-to-noise deliver consistent, accurate results.
Familiar Sandwich Format: Uses a standard sandwich immunoassay that ELISA-trained labs can adopt easily while maintaining high sensitivity for Aβ1-42.
Automation-compatible Design: Engineered for seamless integration with automated liquid-handling platforms to streamline workflows and reduce manual steps. Dedicated Technical Support: Backed by experts experienced in SMC® assay technology.

Packaging
96 well assay
Analysis Note
Sensitivity: LLOQ 580 fg/mL* (SMCxPRO® Instrument)
Standard Curve Range: 290-1,000,000 fg/mL
Intra-assay CV: Inter-assay CV: Linearity: Serum: 93% Plasma: 104% CSF: 97%
Recovery: Serum: 99% Plasma: 104% CSF: 99%
*Indicative LLOQ created from average of 14 independent in house runs, where >80% met same value defined with CV & Recovery +/- 20%. Refer to CoA for lot specific performance.
Other Notes
Although NPTX2 was detectable in non-human primate (rhesus macaque and cynomolgus monkey), feline, rat, mouse, and canine samples, the assay has not been verified for these species.
Legal Information
SMC is a registered trademark of Singulex
SMCxPRO is a registered trademark of Merck KGaA, Darmstadt, Germany
FEMTOQUEST is a trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.