Description
General description
25 Aluminium sheets 20 x 20 cm
Application
Novel Validated HPTLC Method for the Analysis of Two Binary Mixtures Containing Tamsulosin Hydrochloride with Antimuscarinic Agents.: This study presents a novel HPTLC method using aluminum sheets and Silica gel 60 F₂₅₄ for analyzing binary mixtures of Tamsulosin Hydrochloride with antimuscarinic agents. This method ensures accurate and efficient separation of the components (El-Kimary et al., 2018).
Development and Validation of a High-Performance Thin-Layer Chromatographic Method for the Simultaneous Determination of Two Binary Mixtures Containing Ketorolac Tromethamine with Phenylephrine Hydrochloride and with Febuxostat.: This research developed a validated HPTLC method on aluminum sheets coated with Silica gel 60 F₂₅₄ for simultaneous determination of Ketorolac Tromethamine with Phenylephrine Hydrochloride and with Febuxostat, showcasing high accuracy and precision (El Yazbi et al., 2016).
HPTLC Determination of Three Gliptins in Binary Mixtures with Metformin.: The article demonstrates the use of HPTLC aluminum sheets with Silica gel 60 F₂₅₄ for determining three gliptins in binary mixtures with Metformin, emphasizing the method′s efficiency and reliability (El-Kimary et al., 2016).
Validated HPLC and HPTLC methods for simultaneous determination of colchicine and khellin in pharmaceutical formulations.: This paper details validated HPTLC methods on aluminum sheets and Silica gel 60 F₂₅₄ for simultaneous determination of colchicine and khellin, providing a robust and accurate analytical approach (Hadad et al., 2013).
Analysis Note
Specific surface area (according to BET; 5-Pt. measurement): 480 - 540 m²/g
Pore volume (N₂-isotherm): 0.74 - 0.84 ml/g
d 50 (laser diffraction, size distribution): 5 - 7 µm
Layer thickness: 150 - 200 µm
Deviation of layer thickness per plate: ≤ 30 µm
Chromatographic testings:
A) Colour test
hRf-values
- bleu vif organol, colour test, lipophile:
17 - 22
- Ceres Black G, colour test, lipophile: 38 - 43
- ceres Violet brn, colour test, lipophile: 58 - 64
separation number
- colourtest, lipophile:
≥ 10.0
B) Steroid test
hRf-values
- hydrocortisone, steroid test:
23 - 29
- Reichstein S, steroid test: 36 - 45
- methyltestosterone, steroid test: 43 - 52
separation number
- steroid test:
≥ 10.5
Typical value determined on a conditioned sheet
Eluent A) Toluene (45% rel.humidity)
Eluent B) Ethyl acetate/Toluene (95+5 v/v; 20% rel.humidity)
Other Notes
Replaces: 5548-7; 5548
