Neomycin B is one of the major components of neomycin sulfate, an aminoglycoside antibiotic produced by Streptomyces fradiae. It exerts bactericidal effects by binding to the 30S ribosomal subunit, leading to inhibition of protein synthesis and misreading of mRNA. The USP standard supports identification and quantification of this individual neomycin component in complex mixtures.
The USP biologics antibiotics category includes a wide range of antimicrobial agents that are essential in treating bacterial infections. These antibiotics are derived from various natural sources or synthesized to combat specific pathogens effectively. The USP provides comprehensive standards, reference materials, and analytical procedures to ensure the identity, quality, purity, and consistency of antibiotic therapeutics throughout their lifecycle.
The United States Pharmacopeia (USP) provides quality standards for biologics to ensure their safety, efficacy, and quality throughout the manufacturing process. These standards assist manufacturers in adhering to regulatory requirements and help safeguard public health by reducing risks associated with biologics.
| MDL number | MFCD00037007 |
|---|---|
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
| SMILES string | [S](=O)(=O)(O)O.N[C@H]1[C@H](O[C@H]([C@H]([C@@H]1O)O)CN)O[C@@H]2[C@H](O[C@H]([C@@H]2O)O[C@H]3[C@@H]([C@H](C[C@H]([C@@H]3O)N)N)O[C@H]4O[C@@H]([C@H]([C@@H]([C@H]4N)O)O)CN)CO |
| InChI | 1S/C23H46N6O13.H2O4S/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22;1-5(2,3)4/h5-23,30-36H,1-4,24-29H2;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+;/m1./s1 |
| InChI key | OIXVKQDWLFHVGR-WQDIDPJDSA-N |
| API family | neomycin |
| form | solid |
| packaging | pkg of 150 mg |
| manufacturer/tradename | USP |
| web metadata keyword.default | USP Biologics |
| application(s) | USP Biologicspharmaceutical |
| format | neat |
| storage temp. | −20°C |
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