Merck, 164603-50MG, 3-Nitropropionic acid

Name: 3-Nitropropionic acid
Brand: Merck
SKU: 164603-50MG

Size:50 mg, 3-Nitropropionic acid, 3-Nitropropionic acid, 3-NP, 3-NPA, 3NPA, A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme.

Catalog Number: 164603-50MG

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Category

Modifying Enzymes

Pack Size50 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
A cell-permeable, irreversible inactivator (~3 mM) of succinate dehydrogenase that upon oxidation by Complex II forms a covalent adduct with Arg297 in the active site of the enzyme. Disrupts the blood-brain barrier and causes severe energy (ATP) impairment. Also replicates several pathophysiological symptoms of Huntington disease, including spontaneous choreiform and dystonic movements and degeneration of striatum in rodent models. Chronic administration of 3-NP (38 mg/kg/day) is shown to cause activation of c-Jun kinase in striatum.
Packaging
Packaged under inert gas
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Beal, M., et al. 1993, J. Neurosci.13, 4181.
Pang, Z., et al. 1997, J. Neuroscience17, 3064.
Huang, L., et al. 2006, J. Bio. Chem. 281, 5965.
Garcia, M., et al. 2002, J. Neurosci. 22, 2174.
Kim, G. W., et al. 2003, J. Neurosci.23, 8733.
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Toxic (F)

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
Web Name Suffix Override	≥97% (HPLC), Succinate dehydrogenase inactivator, powder
MDL number	MFCD00007406
SMILES string	[N+](=O)([O-])CCC(=O)O
InChI	1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
InChI key	WBLZUCOIBUDNBV-UHFFFAOYSA-N
assay	≥97% (HPLC)
form	powder
manufacturer/tradename	Calbiochem®
storage condition	OK to freeze
color	light yellow
solubility	ethanol: 100 mg/mL
shipped in	ambient
Quality Level	100
storage temp.	2-8°C

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