Merck, 19899-1ML-F, CHAPS 100 mM solution

Name: CHAPS 100 mM solution
Brand: Merck
SKU: 19899-1ML-F

Size:1 mL, CHAPS solution

Catalog Number: 19899-1ML-F

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Category

Zwitterionic Detergents

Pack Size1 mL

TagsChemistry & Biochemicals Biochemicals Detergents

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS) is a biocompatible surfactant. It is a derivative of cholic acid comprising a hydrophobic cholesterol-like skeleton possessing three hydroxyl groups and a zwitterionic aliphatic tail.
Application
CHAPS 100 mM solution has been used as a component of lysis buffer for the extraction of proteins from goat endometrial epithelial cells (EECs) and liver tissue.
Biochem/physiol Actions
3-[(3-cholamidopropyl) dimethylammonio]-1-propanesulfonate (CHAPS) exhibits the properties of both sulfobetaine-type surfactants and bile salts. It is involved in the protein extraction process for proteomic analysis and reconstitution of membrane proteins into lipid vesicles (proteoliposomes). CHAPS is broadly used in biochemistry for membrane protein and receptor isolation and purification. It is conveniently used in pharmaceuticals and medicines due to its biocompatibility, noncharged character, nondenaturing, and disaggregating properties.

Specifications

General

NACRES	NA.25
PubChem Substance ID	57647807
UNSPSC Code	12161902
MDL number	MFCD00012116
InChI	1S/C32H58N2O7S/c1-21(8-11-29(38)33-14-6-15-34(4,5)16-7-17-42(39,40)41)24-9-10-25-30-26(20-28(37)32(24,25)3)31(2)13-12-23(35)18-22(31)19-27(30)36/h21-28,30,35-37H,6-20H2,1-5H3,(H-,33,38,39,40,41)/t21-,22?,23-,24-,25+,26+,27-,28+,30+,31+,32-/m1/s1
SMILES string	C[C@H](CCC(=O)NCCC[N+](C)(C)CCCS([O-])(=O)=O)[C@H]1CC[C@H]2[C@@H]3[C@H](O)CC4C[C@H](O)CC[C@]4(C)[C@H]3C[C@H](O)[C@]12C
InChI key	UMCMPZBLKLEWAF-RFCNGIAKSA-N
description	zwitterionic
form	liquid
mol wt	614.88 g/mol
concentration	100 mM in H2O
technique(s)	protein quantification: suitable
CMC	8 mM
transition temp	cloud point >100 °C
density	1.01 g/mL at 20 °C
storage temp.	2-8°C
Quality Level	100

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