Merck, 200488-10MG, Bestatin Hydrochloride

Name: Bestatin Hydrochloride
Brand: Merck
SKU: 200488-10MG

Size:10 mg, InSolutionBestatin, Hydrochloride, [(2S, 3R)-3-Amino-2-hydroxy-4-phenylbutanoyl]-Leu, HCl, InSolution, ≥98%, a metalloprotease inhibitor

Catalog Number: 200488-10MG

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Category

Dry Ice

Pack Size10 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
A metalloprotease inhibitor. Reversibly binds to cell surfaces and competitively inhibits surface aminopeptidases, notably aminopeptidase B and leucine aminopeptidase. Also acts as a potent aminopeptidase N inhibitor. Activates macrophages and T lymphocytes. Has anti-tumor properties. Effective at a concentration of 1-10 µM. The solid form of this compound (Cat. No. 200484) is also available.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Metalloproteases
Reversible: yes
Packaging
Packaged under inert gas
Physical form
Supplied as a 50 mM (10 mg/580 µL) solution of Bestatatin, HCl in H₂O.
Preparation Note
Following initial, aliquot and freeze (-20°C). Aliquots are stable for up to 6 months at -20°C.
Other Notes
Merck Index: 14, 9842.
Inoue, T., et al. 1994. J. Clin. Endocrinol. Metab.79, 171.
Taylor, A., et al. 1993. Biochemistry32, 784.
Ishida, J.I., et al. 1984. J. Chromatogr.305, 381.
Umezawa, H. 1982. Annu. Rev. Microbiol.36, 75.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Standard Handling (A)

Specifications

General

UNSPSC Code	12352202
NACRES	NA.77
SMILES string	CC(C)C[C@@H](C(O)=O)NC([C@@H](O)[C@H](N)CC1=CC=CC=C1)=O.[xHCl]
assay	≥98% (HPLC)
form	liquid
manufacturer/tradename	Calbiochem®
storage condition	OK to freeze
shipped in	dry ice
storage temp.	−20°C
Quality Level	100

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