Merck, 235135-1GM, Corticosterone

Name: Corticosterone
Brand: Merck
SKU: 235135-1GM

Size:1 g, Corticosterone, (11β)-11, 21-Dihydroxypregn-4-ene-3, 20-dione, Reichstein’s substance H, Corticosteroid hormone synthesized in response to stress.

Catalog Number: 235135-1GM

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Category

Membrane Protein Extraction Kits

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Corticosteroid hormone synthesized in response to stress. Binds to and activates mineralocorticoid and glucocorticoid receptors, resulting in altered genomic expression. Steroid-induced changes in protein synthesis eventually affect ionic conductances through the membrane. Also induces apoptosis in murine bone marrow.
Biochem/physiol Actions
Cell permeable: no
Primary Target
Mineralocorticoid and glucocorticoid receptors
Product does not compete with ATP.
Reversible: no
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Other Notes
Garvy, B.A., et al. 1993. Immunology80, 587.
DeKloet, E.R. 1992. Ann. N.Y. Acad. Sci.663, 357.
Joels, M., and deKloet, E.R. 1992. Trends Neurosci.15, 25.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Carcinogenic / Teratogenic (D)

Specifications

General

UNSPSC Code	12352200
NACRES	NA.77
Web Name Suffix Override	≥95% (HPLC), crystalline powder, corticosteroid hormone, Calbiochem
MDL number	MFCD00037715
SMILES string	O[C@@H]1[C@H]2[C@H]([C@H]4[C@@]([C@H](CC4)C(=O)CO)(C1)C)CCC3=CC(=O)CC[C@@]32C
InChI	1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChI key	OMFXVFTZEKFJBZ-HJTSIMOOSA-N
description	Merck USA index - 14, 2538
assay	≥95% (HPLC)
form	crystalline powder
manufacturer/tradename	Calbiochem®
storage condition	OK to freeze
color	off-white
solubility	ethanol: 50 mg/mL
shipped in	ambient
storage temp.	10-30°C
Quality Level	100

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