Merck, 310500-5MG, D-erythro-Sphingosine, N,N-Dimethyl-

Name: D-erythro-Sphingosine, N,N-Dimethyl-
Brand: Merck
SKU: 310500-5MG

Size:5 mg, D-erythro-Sphingosine, N, N-Dimethyl-, DMS, SK Inhibitor III, Sphingosine Kinase Inhibitor III, A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity.

Catalog Number: 310500-5MG

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Category

Protein-Free Media

Pack Size5 mg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
A cell-permeable and reversible inhibitor of protein kinase C (PKC; IC₅₀ = 12 µM) and stimulates Src kinase activity. Useful for inhibiting cell surface expression of selectins that promote adhesion of leukocytes or tumor cells to platelets and endothelial cells. Induces apoptosis in human leukemia HL-60 cells. An inhibitor of sphingosine kinase.
Biochem/physiol Actions
Cell permeable: yes
Primary Target
PKC
Product does not compete with ATP.
Reversible: yes
Target IC₅₀: 12 µM against PKC
Preparation Note
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Other Notes
Cuvillier, O., et al. 1996. Nature381, 800.
Ohta, H., et al. 1995. Cancer Res.55, 691.
Kimura, S., et al. 1992. Biochem. Pharmacol.44, 1585.
Hanada, K., et al. 1991. Biochemistry30, 11682.
Igarashi, Y., et al. 1990. J. Biol. Chem.265, 5385.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Toxicity: Irritant (B)

Specifications

General

MDL number	MFCD02259309
UNSPSC Code	12352211
NACRES	NA.77
SMILES string	N([C@H]([C@H](O)\C=C\CCCCCCCCCCCCC)CO)(C)C
InChI	1S/C20H41NO2/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(23)19(18-22)21(2)3/h16-17,19-20,22-23H,4-15,18H2,1-3H3/b17-16+/t19-,20+/m0/s1
InChI key	YRXOQXUDKDCXME-YIVRLKKSSA-N
assay	≥98% (TLC)
form	oil (Clear)
manufacturer/tradename	Calbiochem®
storage condition	OK to freeze
solubility	DMSO: 5 mg/mL
shipped in	ambient
storage temp.	−20°C
Quality Level	100

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