Merck, 700022P-1MG, 7-keto-27-hydroxycholesterol

Name: 7-keto-27-hydroxycholesterol
Brand: Merck
SKU: 700022P-1MG

Size:1 mg, 3β, 27-dihydroxy-5-cholesten-7-one, Avanti Research™ - A Croda Brand

Catalog Number: 700022P-1MG

Pricing

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Category

Dry Ice

Pack Size1 mg

TagsChemistry & Biochemicals Biochemicals Avanti Research™A Croda Brand

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
7-keto-27-hydroxycholesterol interconversion to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) is catalyzed by hydroxysteroid 11-β dehydrogenase. It is also formed by the oxidation of 7-oxocholesterol (7-OC) in the presence of enzyme by sterol 26-hydroxylase (CYP27A1).
Application
7-keto-27-hydroxycholesterol has been used as an oxysterol compound to study its interaction with smoothened (SMO) protein, as a substrate to 11β-hydroxysteroid dehydrogenases (11β-HSDs) for kinetic measurement studies,
Biochem/physiol Actions
7-keto-27-hydroxycholesterol (7-OC) acts as an agonist for the smoothened (SMO) protein of Hedgehog (Hh) signalling pathway, which is vital for proper cell differentiation in embryonic tissue. It elicits strong affinity to SMO compared to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC). 7-OC is reduced to 7β,(25R)26-dihydroxycholesterol (7β,26-diHC) by reactive oxygen species (ROS).
Packaging
5 mL Amber Glass Screw Cap Vial (700022P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC

Specifications

General

MDL number	MFCD00057815
NACRES	NA.25
UNSPSC Code	12352211
assay	>99% (TLC)
form	powder
packaging	pkg of 1 × 1 mg (700022P-1mg)
manufacturer/tradename	Avanti Research™ - A Croda Brand
shipped in	dry ice
storage temp.	−20°C

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