Merck, 700044P-1MG, 7β-hydroxycholesterol-d7

General description
7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol. 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.
Application
7β-hydroxycholesterol-d7 has been used:
as cholesterol oxidation product for mass spectroscopy analysis
as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis
as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry
as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification

Biochem/physiol Actions
7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice. 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.
Packaging
5 mL Amber Glass Screw Cap Vial (700044P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC