Merck, 700116P-1MG, 7-dehydrocholesterol-d7

Name: 7-dehydrocholesterol-d7
Brand: Merck
SKU: 700116P-1MG

Size:1 mg, 111110, Avanti Research™ - A Croda Brand

Catalog Number: 700116P-1MG

Pricing

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Category

Dry Ice

Pack Size1 mg

TagsChemistry & Biochemicals Biochemicals Avanti Research™A Croda Brand

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
7-dehydrocholesterol (7-DHC) is a cholesterol precursor and is localized in basal epidermal keratinocytes. 7DHC on photolysis in the presence of ultraviolet light B generates previtamin D3. The enzyme 7-dehydrocholesterol reductase (DHCR7) catalyzes the reduction of C(7-8) double bond of 7-DHC to cholesterol. 7-dehydrocholesterol-d7 is a deuterated derivative of 7-dehydrocholesterol.
Application
7-dehydrocholesterol-d7 has been used:
as an internal standard: to spike Chlamydomonas CC-125 lipid extract for mass spectroscopy analysis
in liquid chromatography–mass spectrometry (LC-MS) for cultured cells oxysterol analysis
to treat and label SRD-1 cell (chinese hamster ovary (CHO) mutant cell-line) for gas chromatography/mass spectrometry (GC/MS) analysis

Biochem/physiol Actions
7-Dehydrocholesterol (7-DHC) is used as a precursor for microbial vitamin D3 production. Impairment of 7-dehydrocholesterol reductase (DHCR7) functionality leads to 7-DHC accumulation and is implicated in Smith-Lemli-Opitz syndrome (SLOS).
Packaging
5 mL Amber Glass Screw Cap Vial (700116P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC

Specifications

General

MDL number	MFCD22570234
UNSPSC Code	41141804
Web Name Suffix Override	Avanti Research™ - A Croda Brand
NACRES	NA.25
SMILES string	O[C@H]1CC[C@@]2([C@H]3CC[C@]4([C@@H](CC[C@@H]4[C@@H](CCCC(C([2H])([2H])[2H])(C([2H])([2H])[2H])[2H])C)C3=CC=C2C1)C)C
InChI	1S/C27H44O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9-10,18-19,21,23-25,28H,6-8,11-17H2,1-5H3/t19-,21+,23-,24+,25+,26+,27-/m1/s1/i1D3,2D3,18D
InChI key	UCTLRSWJYQTBFZ-UDEPUTHCSA-N
assay	>99% (TLC)
form	powder
shipped in	dry ice
storage temp.	−70°C
description	7-dehydrocholesterol-d7
packaging	pkg of 1 × 1 mg (700116P-1mg)
manufacturer/tradename	Avanti Research™ - A Croda Brand

Ordering

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