Merck, 700127P-1MG, 7-keto-25-hydroxycholesterol

Name: 7-keto-25-hydroxycholesterol
Brand: Merck
SKU: 700127P-1MG

Size:1 mg, cholest-5-ene-7-one-3β, 25-diol, 3β, 25-dihydroxy-5-cholesten-7-one, powder

Catalog Number: 700127P-1MG

Pricing

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Category

Dry Ice

Pack Size1 mg

TagsChemistry & Biochemicals Biochemicals Avanti Research™A Croda Brand

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
7-keto-25-hydroxycholesterol synthesis from 7-ketocholesterol is catalyzed by the enzyme cholesterol 25-hydroxylase. 7β,25-dihydroxycholesterol (7β25OHC) is produced from the stereospecific reduction of 7k25OHC by the action of enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). 11β-HSD type 2 enzyme catalyzes the reverse conversion of 7β25OHC to 7k25OHC.
Application
7-keto-25-hydroxycholesterol has been used as a substrate for 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) expressed in human embryonic kidney (HEK)-293 cells to test the oxoreduction functionality of the enzyme. It has also been used to test its effect on Epstein-Barr virus-induced seven-transmembrane receptor (EB12) activation.
Biochem/physiol Actions
7-keto-25-hydroxycholesterol (7k25OHC) might interact with the cysteine-rich domain (CRD) of the smoothened (Smo) in the hedgehog pathway. However, 7-keto-25-OHC is incapable of activating Smo.
Packaging
5 mL Amber Glass Screw Cap Vial (700127P-1mg)
5 mL Amber Glass Screw Cap Vial (700127P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC

Specifications

General

MDL number	MFCD01310734
Web Name Suffix Override	Avanti Research™ - A Croda Brand
NACRES	NA.25
UNSPSC Code	12352211
assay	>99% (TLC)
form	powder
packaging	pkg of 1 × 1 mg (700127P-1mg)
manufacturer/tradename	Avanti Research™ - A Croda Brand 700127P
shipped in	dry ice
storage temp.	−20°C

Ordering

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