Merck, 700140P-5MG, 6-keto-5α-hydroxycholesterol

Name: 6-keto-5α-hydroxycholesterol
Brand: Merck
SKU: 700140P-5MG

Size:5 mg, 3β, 5α-dihydroxy-cholestan-6-one, Avanti Research™ - A Croda Brand 700140P, powder

Catalog Number: 700140P-5MG

Pricing

Send an RFQ.

View RFQ List

Category

Dry Ice

Pack Size5 mg

TagsChemistry & Biochemicals Biochemicals Avanti Research™A Croda Brand

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
6-keto-5α-hydroxycholesterol, also known as 6-oxo-cholestan-3β,5α-diol (OCDO), is synthesized from the oxidation of 5β, 6β-epoxycholesterol in the presence of enzyme cholesterol epoxide hydrolase. It is also synthesized from cholestane-3β,5α,6β-triol by the enzyme 11β-hydroxysteroid dehydrogenase type II . The enzyme 11β-hydroxysteroid dehydrogenase type I catalyzes the reduction of OCDO to cholestane-3β,5α,6β-triol.
Biochem/physiol Actions
6-keto-5α-hydroxycholesterol favors tumor progression. cholestan-6-oxo-3β,5α-diolelicits cytotoxicity towards human bronchial 16-HBE cells and plays a key role in mediating cell necrosis post ozone exposure. It is an oncometabolite, which promotes breast cancer progression and also blocks chemotaxis mediated by polymorphonuclear leukocytes.
Packaging
5 mL Amber Glass Screw Cap Vial (700140P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC

Specifications

General

MDL number	MFCD00271438
UNSPSC Code	12352211
NACRES	NA.25
Web Name Suffix Override	Avanti Research™ - A Croda Brand
SMILES string	O[C@]21[C@@]([C@@H]3[C@H]([C@H]4[C@@]([C@H](CC4)[C@@H](CCCC(C)C)C)(CC3)C)CC2=O)(CC[C@@H](C1)O)C
InChI	1S/C27H46O3/c1-17(2)7-6-8-18(3)21-9-10-22-20-15-24(29)27(30)16-19(28)11-14-26(27,5)23(20)12-13-25(21,22)4/h17-23,28,30H,6-16H2,1-5H3/t18-,19+,20+,21-,22+,23+,25-,26-,27+/m1/s1
InChI key	SJZZRXMQSAXCFD-ZCBMJONGSA-N
assay	>99% (TLC)
form	powder
packaging	pkg of 1 × 5 mg (700140P-5mg)
manufacturer/tradename	Avanti Research™ - A Croda Brand 700140P
shipped in	dry ice
storage temp.	−20°C

Ordering

Notice

Unless otherwise stated, the minimum order amount is USD 1,000.
For orders below USD 1,000, an additional handling fee may apply, or we may arrange local delivery / local handover where available.
All quotations are subject to final confirmation, including product availability, lead time, batch information, shipping cost, and applicable export or handling requirements.
For quotation requests, please send an RFQ from website or contact:

[email protected]

Please send inquiries directly to us in the “To” field. Emails sent via BCC, mass mailing, or with unrelated recipients may be automatically filtered and will not be processed.