Merck, 710337C-5MG, 14:1 Cardiolipin

Name: 14:1 Cardiolipin
Brand: Merck
SKU: 710337C-5MG

Size:5 mg, 1′, 3′-bis[1, 2-dimyristoleoyl-sn-glycero-3-phospho]-glycerol (sodium salt), Avanti Research™ - A Croda Brand 710337C

Catalog Number: 710337C-5MG

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Category

Dry Ice

Pack Size5 mg

TagsChemistry & Biochemicals Biochemicals Avanti Research™A Croda Brand

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
3β,7α-dihydroxy-5-cholestenoic acid is a sterol derived from cholestenoic acid.
Cardiolipin is an anionic phospholipid containing four acyl chains and small headgroup.
Cardiolipin is localized in the inner membrane of mitochondria. It contains 18 carbon atoms, 3-phosphatidyl groups connected via a glycerol bridge. It is an important component of ATP synthase enzyme.
Application
14:1 Cardiolipin may be used as reference standard in liquid chromatography with tandem mass spectrometry (LC-MS-MS). It may also be used in the quantification of mitochondrial phospholipids and yeast respiratory chain complex using mass spectrometry.
Biochem/physiol Actions
Cardiolipin and cytochrome c interaction determines the function of proteins involved in oxidative phosphorylation and apoptosis. Cardiolipin involved in proton uptake pathway maintains the structure of enzymes participating. Cardiolipin controls the mitochondrial function and membrane potential. It offers structural support for the inner mitochondrial membrane and proteins in it. Altered cardiolipin concentration and composition have been implicated in pathological conditions including ischemia, hypothyroidism, aging, heart failure and cardioskeletal myopathy.
TMCL (1,1′,2,2′-tetramyristoyl cardiolipin) bilayers are useful in generating multilamellar vesicles. Defects in the metabolic pathway of cardiolipin is associated with Barth syndrome patients. Liposomes of TMCL with 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC) and cholesterol are potential drug-delivery systems. TMCL displays temperature dependant thermotropic phase transitions.
Packaging
5 mL Clear Glass Sealed Ampule (710337C-25mg)
5 mL Clear Glass Sealed Ampule (710337C-5mg)
ST503: 3 Vial/Ampule Tray with Outer Cardboard Box (3-1/8" x 29/32" x 2-15/16") (710337C-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC

Specifications

General

UNSPSC Code	12352211
NACRES	NA.25
Web Name Suffix Override	Avanti Research™ - A Croda Brand
InChI key	KMIXSFXJUMNKKR-IVOFNDPZSA-L
SMILES string	O=P([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O)OCC([H])(O)COP([O-])(OC[C@]([H])(OC(CCCCCCC/C=C\CCCC)=O)COC(CCCCCCC/C=C\CCCC)=O)=O.[Na+].[Na+]
assay	>99% (TLC)
form	liquid
packaging	pkg of 1 × 1 mL (710337C-5mg)
manufacturer/tradename	Avanti Research™ - A Croda Brand 710337C
concentration	10 mg/mL (710337C-25mg)
lipid type	phospholipidscardiolipins
shipped in	dry ice
storage temp.	−20°C

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