Merck, 765309-1ML, Gold nanoparticles

Name: Gold nanoparticles
Brand: Merck
SKU: 765309-1ML

Size:1 mL, Gold nanoparticles NH₂ functionalized, Au NP NH₂, Gold Colloid, 10 nm diameter, amine functionalized, PEG 5000 coated, OD 50, dispersion in H₂O

Catalog Number: 765309-1ML

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Category

Gold Nanoparticles

Pack Size1 mL

TagsMaterials Science Electronic Materials Inorganic & Metallic Nanomaterials

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Gold nanoparticles (AuNPs) ranging from 2-200nm in diameter find applications in diverse fields. They show excellent biocompatibility and attractive physicochemical properties. Poly (ethylene) glycol (PEG) surface coatings on gold nanoparticles help in the reduction of protein adsorption, reduce nonspecific interactions with cells and greatly improve the pharmokinetics of these nanoparticles and reduce aggregation of the nanoparticles. PEG layer density depends inversely on the AuNP curvature. Denser coating was possible on smaller AuNPs. AuNPs coated with PEG 5000 exhibited highest colloidal stability. Amine functionalized GNPs which have Poly Ethylene Glycol (PEG) as the ligand or carrier molecule forms a conjugate with siRNA and is extremely useful in RNAi technology. Since it adheres to cell membranes, it may find use in cellular and intracellular targeting in targeted drug delivery applications and also used in biodistribution studies.
Application
Functionalized particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.
Several other specific applications have been listed below:

Since they adhere to cell membranes, AuNPs may be used in cellular and intracellular targeting in targeted drug delivery applications and can also be used in biodistribution studies
AuNPs may also be used in photothermal therapy and radiotherapy
Proposed applications of gold nanoparticles are as:drug delivery agents for cancer therapy, coatings, plastics, nanowire, nanofiber, textiles, catalyst applications.
They may also be used in carrying siRNA which acts against human prostate carcinoma cells by inhibiting a specific cancer gene.

Features and Benefits

A negatively charged siRNA-PEG complex, attached to positively charged GNPs, is easily cleavable in reductive cytosolic environment thus enabling the release of siRNA into cytosol.
The PEG coating decreases the cytotoxicity and increases efficiency of GNPs. PEG increases the stability of the nanoparticles and prevents agglomeration.

Specifications

General

NACRES	NA.23
UNSPSC Code	12162002
material	PEG 5000
form	dispersion in H2O
packaging	glass bottle of 1 mL
OD	50
diameter	10 nm
pH	6.0-8.0 (25 °C)
solubility	water: miscible
density	1.00 g/cm3
λ<sub>max</sub>	520 nm
functional group	amine
storage temp.	2-8°C
Quality Level	100

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