Merck, 810174P-1MG, 16:0-12:0 NBD PA

General description
Phosphatidic acid (PA) is a simple anionic cellular glycerophospholipid possessing a phosphomonoester polar head group and two long hydrophobic acyl chains. 7-nitro-2-1,3-benzoxadiazol-4-yl (NBD) PA is a fluorophore labeled phospholipid having 7-nitrobenz-2-oxa-1,3-diazol-4-yl (NBD) at the sn-2 fatty acid of PA.
Application
16:0-12:0 NBD PA or 1-palmitoyl-2-{12-[(7-nitro-2-1,3-benzoxadiazol-4-yl)amino]dodecanoyl}-sn-glycero-3-phosphate (ammonium salt) is suitable:
to incubate cells for the imaging of lyso phosphatidylcholine (PC) in P. falciparum live cells
as a component of separation buffer for the separation of phosphoinositides and sphingolipids in the microchip devices
in cytidine diphosphate diacylglycerol (CDP-DAG) synthase activity assay

Biochem/physiol Actions
Phosphatidic acid (PA) influences membrane fusion and membrane fission events and membrane curvature. It acts as a signaling molecule for various cellular processes including membrane trafficking and sperm hyper-activation.
Packaging
5 mL Amber Glass Screw Cap Vial (810174P-1mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC