Merck, 860820P-5MG, 20:0(2S-OH) Ceramide

Name: 20:0(2S-OH) Ceramide
Brand: Merck
SKU: 860820P-5MG

Size:5 mg, N-(2′-(S)-hydroxyarachidoyl)-D-erythro-sphingosine, Avanti Research™ - A Croda Brand 860820P, powder

Catalog Number: 860820P-5MG

Pricing

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Category

Dry Ice

Pack Size5 mg

TagsChemistry & Biochemicals Biochemicals Avanti Research™A Croda Brand

CollectionsMerck Biochemicals Collection: Trusted Lab Reagents & Buffers Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Ceramides linked to 2-hydroxy fatty acids (hFA) are present in the surface epithelium of the skin. 20:0(2S-OH) Ceramide is a unique ceramide containing 20C long chain base fatty acid (arachidic acid)-with 2′-hydroxyl group in S configuration.
Biochem/physiol Actions
Hydroxy fatty acid (hFA)-sphingolipids help in formation and function of myelin. In addition, they also play a vital role in cell signaling, cell differentiation and apoptosis. In epidermis, hFA-ceramides aid in permeability barrier function. NAD(P)H-dependent enzyme, fatty acid 2-hydroxylase (FA2H) catalyzes the synthesis of hFA-ceramides. FA2H gene mutation leads to the development of neurological disorders such as leukodystrophy and spastic paraparesis in humans. hFA-ceramides help PM02734 (elisidepsin), an antitumor drug to exhibit its activity.
Packaging
5 mL Amber Glass Screw Cap Vial (860820P-5mg)
Legal Information
Avanti Research is a trademark of Avanti Polar Lipids, LLC

Specifications

General

MDL number	MFCD22416676
UNSPSC Code	12352211
NACRES	NA.25
Web Name Suffix Override	Avanti Research™ - A Croda Brand
InChI	1S/C38H75NO4/c1-3-5-7-9-11-13-15-17-18-19-21-23-25-27-29-31-33-37(42)38(43)39-35(34-40)36(41)32-30-28-26-24-22-20-16-14-12-10-8-6-4-2/h30,32,35-37,40-42H,3-29,31,33-34H2,1-2H3,(H,39,43)/b32-30+/t35-,36+,37-/m0/s1
InChI key	CFYLSUZUMMPFNC-GBPFXZCASA-N
SMILES string	CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](NC([C@@H](O)CCCCCCCCCCCCCCCCCC)=O)CO
assay	>99% (TLC)
form	powder
packaging	pkg of 1 × 5 mg (860820P-5mg)
manufacturer/tradename	Avanti Research™ - A Croda Brand 860820P
lipid type	sphingolipids
shipped in	dry ice
storage temp.	−20°C

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