Merck, 901841-500MG, N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone)

Name: N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone)
Brand: Merck
SKU: 901841-500MG

Size:500 mg, NHS ester PEG-PCL diblock copolymer, NHS ester-PEG-PCL, PEG-b-PCL, PEG-PCL, PEG average Mn 5, 000, PCL average Mn 5, 000

Catalog Number: 901841-500MG

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Category

Functional Polymers

Pack Size500 mg

TagsMaterials Science Biomedical Materials Biomedical Polymers

CollectionsBiomedical Materials by Merck: PEGs, Hydrogels & Bioinks Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
N-Hydroxysuccinimide ester-poly(ethylene glycol)-b-poly(ε-caprolactone) is a functionalized, amphiphilic, diblock copolymer composed of a hydrophilic PEG block and a hydrophobic PCL block. These biodegradable, biocompatible polymers can self-assemble to form nanoparticles, such as micelles and polymersomes, in both aqueous and non-aqueous media. Due to these properties, these polymers are widely used in polymeric nanoparticle formulation to achieve controlled and targeted delivery of therapeutic agents (e.g. APIs, genetic material, peptides, vaccines, and antibiotics). Additionally, well-defined nanoparticles with tunable size and properties can be prepared by altering the molecular weight ratios between hydrophilic and hydrophobic blocks, as well as by controlling formulation parameters. The NHS ester functional group on the PEG chain enables rapid and facile surface functionalization, allowing for these materials to be used in applications such as targeted drug delivery.

Specifications

General

NACRES	NA.23
UNSPSC Code	12352005
form	powder or solid
mol wt	PCL average Mn 5,000
color	white to off-white
PDI	≤1.3 (by GPC)
storage temp.	−20°C

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