Merck, 920789-50MG, Pomalidomide-pyridine-PEG1-piperazine hydrochloride

Name: Pomalidomide-pyridine-PEG1-piperazine hydrochloride
Brand: Merck
SKU: 920789-50MG

Size:50 mg, N-(2-(2, 6-Dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-4-yl)-2-(6-(3-(piperazin-1-yl)propoxy)pyridin-3-yl)acetamide hydrochloride, Crosslinker−E3 Ligase ligand conjugate, Protein degrader building block for PROTAC® research, Template for synthesis of targeted protein degrader

Catalog Number: 920789-50MG

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Category

Protein Crosslinkers

Pack Size50 mg

TagsChemistry & Biochemicals Chemical Biology Protein Degrader Building Blocks

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Protein degrader building block Pomalidomide-pyridine-PEG₁-piperazine hydrochloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand, a linker with added rigidity, and a pendant amine for reactivity with a carboxylic acid on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Other Notes
Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation

Portal: Building PROTAC® Degraders for Targeted Protein Degradation

Targeted Protein Degradation by Small Molecules

Small-Molecule PROTACS: New Approaches to Protein Degradation

Targeted Protein Degradation: from Chemical Biology to Drug Discovery

Impact of linker length on the activity of PROTACs
Legal Information
PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

General

MDL number	MFCD34549907
UNSPSC Code	12352200
NACRES	NA.22
InChI	1S/C27H30N6O6.ClH/c34-21-7-6-20(25(36)31-21)33-26(37)18-3-1-4-19(24(18)27(33)38)30-22(35)15-17-5-8-23(29-16-17)39-14-2-11-32-12-9-28-10-13-32;/h1,3-5,8,16,20,28H,2,6-7,9-15H2,(H,30,35)(H,31,34,36);1H
InChI key	NQWAQGYTEGUDBW-UHFFFAOYSA-N
SMILES string	O=C(N(C1CCC(NC1=O)=O)C2=O)C3=C2C=CC=C3NC(CC4=CC=C(OCCCN5CCNCC5)N=C4)=O.Cl
ligand	pomalidomide
form	powder or crystals
reaction suitability	reactivity: carboxyl reactive
functional group	amine
storage temp.	2-8°C
Quality Level	100

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