Merck, C4733-50UG, BID, Caspase-8-cleaved from mouse

Name: BID, Caspase-8-cleaved from mouse
Brand: Merck
SKU: C4733-50UG

Size:50 μg, ≥95% (SDS-PAGE), recombinant, expressed in E. coli, buffered aqueous solution

Catalog Number: C4733-50UG

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Category

Dry Ice

Pack Size50 µg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Mouse BID cleaved with caspase-8 generates the amino-terminal fragment (amino acids 1-59, 7 kDa) and the carboxy-terminal fragment (amino acids 60-195, 15 kDa). On size exclusion chromatography cleaved BID elutes at 27 kDa indicating that the fragments remain associated.
Biochem/physiol Actions
Caspase-8-cleaved BID relocates from the cytosol to the outer mitochondrial membrane where its interaction with Bak alters mitochondrial membrane permeability.
Physical form
0.2 μm filtered solution in 25 mM HEPES, pH 7.5, and 0.1 M KCl.
Analysis Note
Measured by its ability to induce cytochrome c release from isolated mouse liver mitochondria.

Specifications

General

UNSPSC Code	12352202
NACRES	NA.32
MDL number	MFCD03456214
recombinant	expressed in E. coli
assay	≥95% (SDS-PAGE)
form	buffered aqueous solution
UniProt accession no.	P70444
shipped in	dry ice
storage temp.	−20°C
Quality Level	200
Gene Information	mouse ... Bid(12122)

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