Merck, CC077, Human Collagen Type V

Name: Human Collagen Type V
Brand: Merck
SKU: CC077

Size:100 μg, Collagen Type V, 1 mg/mL, solution, BioReagent, suitable for cell culture

Catalog Number: CC077

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Category

Differentiation Factors

Pack Size100 µg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Attachment Factors

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Collagen type V is fibril-forming collagen that is located in the lung, bone, and fetal membranes along with type I collagen. It is minor collagen present in the extracellular matrix.
Application
Human Collagen Type V has been used to study the interaction of high endothelial venule protein (hevin) with human collagen V by fluorescence polarization (FP) assay and surface plasmon resonance(SPR). It has also been used to incubate the 96 well plate to determine the protein levels in media and cell lysates of fibroblasts.
Biochem/physiol Actions
Collagen type V acts as a regulator of collagen fibrillogenesis in the cornea and skin dermis. It interacts with matrix collagens and structural proteins thereby contributing to the structural integrity of tissues. Lower levels of type V collagen lead to loss of corneal transparency and Ehler Danlos syndrome.
Physical form
Liquid, in 0.1M acetic acid, pH 3.0. No preservatives added.
Preparation Note
Maintain at -20°C in undiluted aliquots for up to 12 months. Do not thaw and refreeze.
Purified by serial salt precipitations of a pepsin extraction of human fetal membranes and chromatography on DEAE-cellulose.
Other Notes
Molecular composition: α1(V)]2 α2(V), native triple helix. Purity and retention of the native helical structure were monitored by SDS-PAGE, ORD measurement, and by reaction with anti-collagen type-specific monoclonal antibodies. Product Source: Human placenta, negative for HBsAg and HIV antibodies.
Legal Information
CHEMICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
RESEARCH USE ONLY. This product is regulated in France when intended to be used for scientific purposes, including for import and export activities (Article L 1211-1 paragraph 2 of the Public Health Code). The purchaser (i.e. enduser) is required to obtain an import authorization from the France Ministry of Research referred in the Article L1245-5-1 II. of Public Health Code. By ordering this product, you are confirming that you have obtained the proper import authorization.

Specifications

General

UNSPSC Code	12352202
eCl@ss	32160405
Web Name Suffix Override	from human placenta, liquid, 1 mg/mL, suitable for cell culture, used for gel formation
NACRES	NA.75
biological source	human
assay	95% (SDS-PAGE)
form	solution
manufacturer/tradename	Chemicon®
concentration	1 mg/mL
technique(s)	cell culture \| mammalian: suitable
impurities	<0.5% non-collagen proteins
input	sample type mesenchymal stem cell(s)sample type induced pluripotent stem cell(s)sample type pancreatic stem cell(s)sample type epithelial cellssample type neural stem cell(s)sample type hematopoietic stem cell(s)sample type: human embryonic stem cell(s)
NCBI accession no.	NM_000093.3
UniProt accession no.	P20908
shipped in	dry ice
storage temp.	−20°C
Quality Level	200
Gene Information	human ... COL5A1(1289), COL5A2(1290)

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