Merck, D3072-1ML, Doxycycline Hydrochloride, Ready Made Solution

Name: Doxycycline Hydrochloride, Ready Made Solution
Brand: Merck
SKU: D3072-1ML

Size:1 mL, α-6-Deoxy-5-hydroxytetracycline hydrochloride, 2-Naphthacenecarboxamide, 4-(dimethylamino)- 1, 4, 4a, 5, 5a, 6, 11, 12a-octahydro-3, 5, 10, 12, 12a-pentahydroxy-6-methyl-1, 11-dioxo-, hydrochloride (1:1), (4S, 4aR, 5S, 5aR, 6R, 12aS)-, Doxylin, Idocyklin, Vibramycin hyclate, Vibramycin hydrochloride, 100 mg/mL in DMSO, ≥95.0% (HPLC)

Catalog Number: D3072-1ML

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Category

Antibiotics & Antimycotics

Pack Size1 mL

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Antibiotics

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Doxycycline is a member of the tetracycline antibiotics group, and is commonly used to treat a variety of infections. It is a Broad spectrum antibiotic and bacteriostatic. Doxycycline shows antiprotozoal properties and is a potent inhibitor of MMPs (matrix metalloproteinases) in vivo.
Application

AAPS PharmSciTech: Creation of a PVA/PCL/CS-based nanofibrous membrane incorporating doxycycline hydrochloride for guided tissue regeneration and controlled delivery in the management of periodontitis, evaluated in vivo in rats (Mirzaeei et al., 2024).

European Journal of Pharmacology: Doxycycline hydrochloride′s role in inhibiting the progression of malignant rhabdoid tumor of the kidney by targeting MMP17 and MMP1 through the PI3K-Akt signaling pathway (Mi et al., 2024).

Other Notes
Keep container tightly closed in a dry and well-ventilated place. Containers which are opened must be carefully resealed and kept upright to prevent leakage.

Specifications

General

NACRES	NA.85
UNSPSC Code	51284028
MDL number	MFCD03427564
InChI	1S/C22H24N2O8.ClH/c1-7-8-5-4-6-9(25)11(8)16(26)12-10(7)17(27)14-15(24(2)3)18(28)13(21(23)31)20(30)22(14,32)19(12)29;/h4-7,10,14-15,17,25-27,31-32H,23H2,1-3H3;1H/b21-13-;/t7-,10+,14+,15-,17-,22-;/m0./s1
InChI key	VLUQVUWDECWBTL-UQVCFKGQSA-N
biological source	synthetic
sterility	0.22 μm filtered
assay	≥95.0% (HPLC)
form	liquid
concentration	100 mg/mL in DMSO
solubility	DMSO: 100 mg/mL
antibiotic activity spectrum	Gram-negative bacteria
mode of action	protein synthesis \| interferes
storage temp.	−20°C
Quality Level	200

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