Merck, E0162-1VL, Carboxylesterase 1 isoform c human

Name: Carboxylesterase 1 isoform c human
Brand: Merck
SKU: E0162-1VL

Size:1 vial, Carboxylesterase 1 human, carboxylesterase, esterase, recombinant, expressed in baculovirus infected BTI insect cells

Catalog Number: E0162-1VL

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Category

Recombinant Enzymes

Pack Size1 vials

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Carboxylesterase 1 (CE1) is a member of a large multigene carboxylesterase α,β-hydrolase family. It is majorly expressed in the liver. CE1 comprises an αβ domain, a central catalytic domain and a regulatory domain.
This product is offered in a volume of 0.5 mL.
Application
Carboxylesterase 1 isoform c human has been used as a reference standard in carboxylesterase activity from the mussel for comparison of substrate specificity and inhibition studies. It has also been used as a commercial recombinant protein for the methodological validation of environmental chemical-based inhibition studies.
Biochem/physiol Actions
Carboxylesterase enzymes are responsible for the hydrolysis of ester- and amide-bond-containing drugs such as cocaine and heroin. They also hydrolyze long-chain fatty acid esters and thioesters. Carboxylesterase 1 (CE1) catalyzes the formation of cholesteryl esters from cholesterol and fatty acids. Through a transesterification reaction, CE1 also mediates the generation of fatty acid ethyl esters (FAEEs). It also hydrolyzes aromatic and aliphatic esters with preference to small alcohol groups and bulky acyl groups. CE1 metabolizes drug esters and amides carbamates. It participates in the detoxification of environmental toxicants and carcinogens and is useful in pharmacokinetic studies for evaluating pro-drugs.
Other Notes
One unit will hydrolyze one nanomole of 4-nitrophenyl acetate per minute at pH 7.4 at 37 °C.

Specifications

General

UNSPSC Code	12352204
EC Number	232-773-7
NACRES	NA.54
Enzyme Commission (EC) Number	3.1.1.1 ( BRENDA \| IUBMB )
recombinant	expressed in baculovirus infected BTI insect cells
form	liquid
concentration	≥0.3 mg/mL
shipped in	dry ice
storage temp.	−70°C
Quality Level	200

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