Merck, N1142-20ML, Neomycin solution

Name: Neomycin solution
Brand: Merck
SKU: N1142-20ML

Size:20 mL, Antibiotic 10676, Neomycin B, with 10 mg/mL neomycin in 0.9% NaCl, 0.1 μm filtered, BioReagent, suitable for cell culture

Catalog Number: N1142-20ML

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Category

Antibiotics & Antimycotics

Pack Size20 mL

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Antibiotics

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Chemical structure: aminoglycoside
Application
Neomycin solution has been used:
as a supplement of autoclaved acidified water for bone marrow transplantation
for the selection of stable clones
as a component of artificial sea water (ASWO) medium to remove bacteria from O. tauri cultures

Biochem/physiol Actions
Neomycin is an aminoglycoside antibiotic, produced by Streptomyces containing a minimum of 85% neomycin B. It acts as a selection agent for prokaryotic cells transformed using the neo selectable marker gene. Neomycin trisulfate is used to study the cytototoxic side effects of antibiotics, platelet-derived growth factor responses in certain fibroblasts and extraction of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins. This product is recommended for use in cell culture applications at 5 mL/L.
Mode of action: This product acts by binding to the 30S and 50S subunits, causing miscoding and inhibiting initiation and elongation during protein synthesis. Neomycin also blocks voltage-sensitive Ca2+ channels without affecting the Na+/Ca2+ antiporter in neurons.
Antimicrobial spectrum: Neomycin acts against both gram-positive and gram-negative bacteria
Disclaimer
This solution is formulated to contain 10 mg/mL neomycin in 0.9% sodium chloride. It is stable at 37 °C for 5 days and should be otherwise stored at 2-8°C.

Specifications

General

UNSPSC Code	12352207
PubChem Substance ID	24897464
NACRES	NA.76
Web Name Override	Neomycin
Web Name Suffix Override	solution, suitable for cell culture, BioReagent
InChI	1S/C23H46N6O13/c24-2-7-13(32)15(34)10(28)21(37-7)40-18-6(27)1-5(26)12(31)20(18)42-23-17(36)19(9(4-30)39-23)41-22-11(29)16(35)14(33)8(3-25)38-22/h5-23,30-36H,1-4,24-29H2/t5-,6+,7-,8+,9-,10-,11-,12+,13-,14-,15-,16-,17-,18-,19-,20-,21-,22-,23+/m1/s1
InChI key	PGBHMTALBVVCIT-VCIWKGPPSA-N
SMILES string	NC[C@H]1O[C@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@H](O)[C@H]2O[C@@H]3O[C@H](CO)[C@@H](O[C@H]4O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]4N)[C@H]3O)[C@H](N)[C@@H](O)[C@@H]1O
biological source	Streptomyces fradiae
sterility	0.1 μm filtered
product line	BioReagent
form	liquid
potency	8-12 mg per mL
packaging	pkg of 20ML
concentration	10 mg/mL in 0.9% NaCl (neomycin)
technique(s)	cell culture \| mammalian: suitable
impurities	endotoxin, tested
color	clear

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