Merck, PHR1165-1G, Naproxen sodium

Name: Naproxen sodium
Brand: Merck
SKU: PHR1165-1G

Size:1 g, (S)-6-Methoxy-α-methyl-2-naphthaleneacetic acid sodium salt, Pharmaceutical Secondary Standard; Certified Reference Material

Catalog Number: PHR1165-1G

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Category

Polymer Standards

Pack Size1 g

TagsChromatography Standards Analytical Chemistry Analytical Chromatography

CollectionsMerck Analytical Chromatography Products & Lab Supplies Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Naproxen sodium (NS) is a sodium salt of propionic acid derivative and demonstrates analgesic, anti-pyretic, and anti-inflammatory properties. It exhibits efficiency in being used as an indomethacin in the treatment of acute musculoskeletal disorders. It belongs to the group of nonsteroidal anti-inflammatory drugs (NSAIDS) and acts by inhibiting the activity of both the cyclooxygenase enzymes, COX-1 & COX-2 and further blocking the synthesis of certain prostaglandins. It is administered in the treatment of ankylosing spondylitis, osteoarthritis, rheumatoid disorders, acute gout, mild to moderate pain, tendonitis, bursitis, dysmenorrhea, fever, and migraine headache. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
Naproxen sodium may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and combined dosage forms by chromatographic and spectrophotometric techniques.
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Biochem/physiol Actions
Cyclooxygenase (Prostaglandin H synthase 1 and 2) inhibitor.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP (PhEur) primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA7178 in the slot below. This is an example certificate only and may not be the lot that you receive.
Values of analytes vary lot to lot.

Specifications

General

NACRES	NA.24
PubChem Substance ID	329823182
UNSPSC Code	41116107
EC Number	247-486-2
MDL number	MFCD00058507
InChI key	CDBRNDSHEYLDJV-FVGYRXGTSA-M
InChI	1S/C14H14O3.Na/c1-9(14(15)16)10-3-4-12-8-13(17-2)6-5-11(12)7-10;/h3-9H,1-2H3,(H,15,16);/q;+1/p-1/t9-;/m0./s1
SMILES string	[Na+].COc1ccc2cc(ccc2c1)[C@H](C)C([O-])=O
grade	certified reference material
agency	traceable to USP 1457403
API family	naproxen
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable
application(s)	pharmaceutical (small molecule)
format	neat
storage temp.	2-30°C
Gene Information	human ... PTGS1(5742), PTGS2(5743)
Quality Level	300

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