Merck, PHR1422-1G, Atorvastatin Calcium

Name: Atorvastatin Calcium
Brand: Merck
SKU: PHR1422-1G

Size:1 g, Atorvastatin hemicalcium salt sesquihydrate, 1H-Pyrrole-1-heptanoic acid, [R-(R*, R*)]-2-(4-flurophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl], calcium salt (2:1), Pharmaceutical Secondary Standard; Certified Reference Material

Catalog Number: PHR1422-1G

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Category

Certified Reference Materials

Pack Size1 g

TagsAnalytical Chemistry Reference Materials Certified Reference Materials

CollectionsMerck Certified Reference Materials: CRMs for Calibration, QC & Instrument Validation Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Atorvastatin Calcium is a synthetic cholesterol lowering agent, which acts as an inhibitor of 3-hydroxy-3-methyl glutaryl coenzyme A reductase. It is widely used in combination with amlodipine besylate as a medication in the treatment of vasospastic angina, hypertension, chronic stable angina and primary dysbetalipoproteinemia.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Azathioprine may be used as a pharmaceutical reference standard for the quantification of the analyte in pharmaceutical formulations using reversed-phase high-performance liquid chromatography (RP-HPLC) and spectrophotometric techniques.
Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAC0148 in the slot below. This is an example certificate only and may not be the lot that you receive.

Specifications

General

UNSPSC Code	41116107
NACRES	NA.24
API family	atorvastatin
SMILES string	[Ca+2].Fc5ccc(cc5)c6[n](c(c(c6c8ccccc8)C(=O)Nc7ccccc7)C(C)C)CC[C@@H](O)C[C@@H](O)CC(=O)O.Fc1ccc(cc1)c2[n](c(c(c2c4ccccc4)\C(=N\c3ccccc3)\[O-])C(C)C)CC[C@@H](O)C[C@@H](O)CC(=O)[O-].O.O.O
InChI	1S/2C33H35FN2O5.Ca.3H2O/c21-21(2)31-30(33(41)35-25-11-7-4-8-12-25)29(22-9-5-3-6-10-22)32(23-13-15-24(34)16-14-23)36(31)18-17-26(37)19-27(38)20-28(39)40;;;;/h23-16,21,26-27,37-38H,17-20H2,1-2H3,(H,35,41)(H,39,40);;31H2/q;;+2;;;/p-2/t226-,27-;;;;/m11..../s1
InChI key	SHZPNDRIDUBNMH-NIJVSVLQSA-L
grade	certified reference material
agency	traceable to Ph. Eur. Y0001327
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable
application(s)	pharmaceutical (small molecule)
format	neat
storage temp.	2-30°C
Quality Level	300

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