Merck, PHR1424-1G, Ampicillin Sodium

Name: Ampicillin Sodium
Brand: Merck
SKU: PHR1424-1G

Size:1 g, Ampicillin sodium salt, D-(−)-α-Aminobenzylpenicillin sodium salt, Pharmaceutical Secondary Standard; Certified Reference Material

Catalog Number: PHR1424-1G

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Category

Certified Reference Materials

Pack Size1 g

TagsAnalytical Chemistry Reference Materials Certified Reference Materials

CollectionsMerck Certified Reference Materials: CRMs for Calibration, QC & Instrument Validation Merck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Application
These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.
Ampicillin Sodium may be used as a pharmaceutical secondary reference standard for the determination of the analyte in pharmaceutical formulations by high performance liquid chromatography with ultra violet detection and second-derivative spectrophotometry, respectively.
Biochem/physiol Actions
Mode of Action: This is a β-lactam antibiotic that inhibits bacterial cell-wall synthesis by inactivating transpeptidases on the inner surface of the bacterial cell membrane.

Mode of Resistance: Administration with β-lactamase cleaves the β-lactam ring of Ampicillin and inactivates it.

Antimicrobial Spectrum: Includes both gram-positive (similar to benzylpenicillin) and gram-negative bacteria (similar to tetracyclines and chloramphenicol.

Analysis Note
These secondary standards offer multi-traceability to the USP and EP primary standards, where they are available.
Other Notes
This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.
To see an example of a Certificate of Analysis for this material enter LRAA2732 in the slot below. This is an example certificate only and may not be the lot that you receive.

Specifications

General

UNSPSC Code	41116107
NACRES	NA.24
PubChem Substance ID	329822591
EC Number	200-708-1
Beilstein/REAXYS Number	4119211
MDL number	MFCD00064313
SMILES string	[Na+].CC1(C)SC2[C@H](NC(=O)[C@H](N)c3ccccc3)C(=O)N2[C@H]1C([O-])=O
grade	certified reference material
agency	traceable to Ph. Eur. A1000000
API family	ampicillin
CofA	current certificate can be downloaded
technique(s)	HPLC: suitable
mp	215 °C (dec.) (lit.)
application(s)	pharmaceutical (small molecule)
format	neat
storage temp.	2-30°C
Quality Level	300
InChI key	KLOHDWPABZXLGI-YWUHCJSESA-M
InChI	1S/C16H19N3O4S.Na/c1-16(2)11(15(22)23)19-13(21)10(14(19)24-16)18-12(20)9(17)8-6-4-3-5-7-8;/h3-7,9-11,14H,17H2,1-2H3,(H,18,20)(H,22,23);/q;+1/p-1/t9-,10-,11+,14-;/m1./s1

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