Merck, RDD039-100G, Imidazole

Name: Imidazole
Brand: Merck
SKU: RDD039-100G

Size:100 g, 1, 3-diazole, 1, 3-Diaza-2, 4-cyclopentadiene, Glyoxaline, Molecular Biology, ≥99% (titration), free-flowing, Redi-Dri™

Catalog Number: RDD039-100G

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Category

DNA Extraction Kits

Pack Size100 g

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Imidazole is a heterocyclic compound with a five-membered planar ring. It is amphoteric and highly polar.
Application
Excellent for buffers in the range of pH 6.2-7.8
Imidazole has been usedin the lysis, wash, and elution buffer for the purification of histidine tagged proteins
in gradient for the purification of histidine tagged proteins using nickel affinity chromatography
as a component of homogenization buffer for the purification of phagosomal compartments from dendritic cells

Biochem/physiol Actions
Imidazole derivatives have antibacterial, antifungal and anticancer functionality. It interacts with DNA and also binds to protein and stops cell division. It also acts as a microtubule destabilizing agents and inhibits topoisomerase and Cytochrome P450 Family 26 Subfamily A Member 1 (CYP26A1) enzymes. Imidazole based anticancer drug find applications in cancer chemotherapy. It is used as buffer component for purification of the histidine tagged recombinant proteins in immobilized metal-affinity chromatography (IMAC).
Features and Benefits
Qualified for molecular biology applications, DNase, Rnase, and protease free
Redi-Dri™ packaging controls moisture, eliminating clumps
Crystalline powder remains free-flowing and much easier to use
Safer to handle and weigh out for routine use in lab
Less waste, loss of drying, while maintaining high quality

Other Notes
For additional information on our range of Biochemicals, please complete this form.
Legal Information
Redi-Dri is a trademark of Sigma-Aldrich Co. LLC

Specifications

General

NACRES	NA.21
UNSPSC Code	12352200
Beilstein/REAXYS Number	103853
MDL number	MFCD00005183
eCl@ss	39161001
SMILES string	c1c[nH]cn1
InChI key	RAXXELZNTBOGNW-UHFFFAOYSA-N
InChI	1S/C3H4N2/c1-2-5-3-4-1/h1-3H,(H,4,5)
grade	Molecular Biology
vapor pressure	<1 mmHg ( 20 °C)
product line	Redi-Dri™
assay	≥99% (titration)
form	crystalline powder
quality	free-flowing
pH	6.2-7.8 (25 °C)
pKa (25 °C)	6.95
bp	256 °C (lit.)
Quality Level	100
mp	88-91 °C (lit.)
application(s)	diagnostic assay manufacturing
foreign activity	DNase, RNase and protease, none detected

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