Merck, SRP3003-10UG, Activin A human

Name: Activin A human
Brand: Merck
SKU: SRP3003-10UG

Size:10 μg, Activin beta-A, FRP, Inhibin beta-1, recombinant, expressed in E. coli, ≥97% (SDS-PAGE), ≥97% (HPLC), suitable for cell culture

Catalog Number: SRP3003-10UG

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Category

Growth Factors & Cytokines

Pack Size10 µg

TagsCell Culture & Analysis Cell Culture Supplements & Reagents Growth Factors & Cytokines

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Activins (also referred to as inhibins) are generally dimers of three subunits: inhibin βA, inhibin βB, and inhibin α. Recombinant human Activin A (inhibin βA) is a 26kDa disulfide-linked homodimer of two bA chains, each containing 116 amino acid residues. The sequence of mature Activin A is completely homologous between human, mouse, and rat species.
Application
Activin A has been used in monolayer induction for endoderm (hepatocyte) differentiation.
Activin A human has been used to study rRNA gene transcription during directed differentiation of human embryonic stem cells.
Biochem/physiol Actions
Activin A (inhibin βA) is a TGF (transforming growth factor)-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. Activin A plays a central role in reproduction by regulating the levels of follicle stimulating hormone (FSH). It is involved in hematopoiesis, embryogenesis and osteogenesis. It exhibits both tumor suppressing and promoting effects. In underweight and overweight humans, high levels of Activin A in serum might be associated with the pathogenesis of asthma. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin.
Physical form
Lyophilized with no additives.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Other Notes
GLECDGKVNI CCKKQFFVSF KDIGWNDWII APSGYHANYC EGECPSHIAG TSGSSLSFHS TVINHYRMRG HSPFANLKSC CVPTKLRPMS MLYYDDGQNI IKKDIQNMIV EECGCS

Specifications

General

NACRES	NA.32
UNSPSC Code	12352202
biological source	human
recombinant	expressed in E. coli
assay	≥97% (HPLC)
form	lyophilized
potency	≤2.0 ng/mL ED50
mol wt	26.0 kDa
packaging	pkg of 10 μg
technique(s)	cell culture \| mammalian: suitable
impurities	<0.1 EU/μg endotoxin, tested
UniProt accession no.	P08476
shipped in	wet ice
storage temp.	−20°C
Gene Information	human ... INHBA(3624) mouse ... Inhba(16323) rat ... Inhba(29200)

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