Merck, SRP3031-100UG, Endostatin human

Name: Endostatin human
Brand: Merck
SKU: SRP3031-100UG

Size:100 μg, COL18A1, recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture

Catalog Number: SRP3031-100UG

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Category

Human Primary Cells

Pack Size100 µg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

General description
Research area: Cell Signaling

Endostatin is an endogenous glycoprotein derived from the C-terminal portion of the α1 chain of type XVIII collagen. It is encoded by the gene mapped to human chromosome 21q22.3. Recombinant human Endostatin protein consists of 184 amino acid residues. It is expressed in various organs with the highest levels in liver, lung, and kidney.
Biochem/physiol Actions
Endostatin is a potent inhibitor of angiogenesis. It exerts its angiostatic effect through multiple pathways related to endothelial cell migration and proliferation. Endostatin inhibits and suppresses the actions of matrix metalloproteinases (MMPs), FAK (Focal adhesion kinase)/Ras/p38-MAPK (mitogen-activated protein kinase)/ERK (extracellular signal-regulated kinase) signaling cascade, HIF-1α(hypoxia-inducible factor 1 alpha)/VEGF-A (vascular endothelial growth factor)thereby inhibiting angiogenesis by preventing the migration and invasion of endothelial cells. Endostatin also blocks the apoptosis of cells and the G1 to S phase transition in the cell cycle. Mutations in this gene lead to Knobloch syndrome (KS), a rare autosomal recessive disorder.
Physical form
Lyophilized from 10 mM Sodium Phosphate, pH 7.5.
Preparation Note
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Other Notes
MHSHRDFQPV LHLVALNSPL SGGMRGIRGA DFQCFQQARA VGLAGTFRAF LSSRLQDLYS IVRRADRAAV PIVNLKDELL FPSWEALFSG SEGPLKPGAR IFSFDGKDVL RHPTWPQKSV WHGSDPNGRR LTESYCETWR TEAPSATGQA SSLLGGRLLG QSAASCHHAY IVLCIENSFM TASK

Specifications

General

NACRES	NA.32
UNSPSC Code	12352200
biological source	human
recombinant	expressed in E. coli
assay	≥98% (HPLC)
form	lyophilized
mol wt	20.2 kDa
packaging	pkg of 100 μg
technique(s)	cell culture \| mammalian: suitable
impurities	<0.1 EU/μg endotoxin, tested
color	white to off-white
UniProt accession no.	P39060
shipped in	wet ice
storage temp.	−20°C
Gene Information	human ... COL18A1(80781)

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