Merck, Z2126-20UG, ZAP-70 Tyrosine Kinase human

Name: ZAP-70 Tyrosine Kinase human
Brand: Merck
SKU: Z2126-20UG

Size:20 μg, ≥90% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells (Histidine tagged), buffered aqueous glycerol solution, ≥150 U/mg

Catalog Number: Z2126-20UG

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Category

Insect Cell Expression Systems

Pack Size20 µg

CollectionsMerck Cell Culture Supplements & Reagents: Complete Solutions for Research & Bioproduction Merck Roche Life Science Products for PCR, RT‑PCR & Nucleic Acid Purification

Description

Application
Human ZAP-70 Tyrosine Kinase was used for mapping the phosphorylation sites on LAT (linker for activation of T cells) for investigating the mechanism of activation of signalling proteins in T cells.
Biochem/physiol Actions
ZAP-70 Tyrosine Kinase is a protein belongs to Syk family and is essential for T cell activation. It facilitates the upregulation of Fas ligand in activation-induced T cell apoptosis. Additionally, it also plays a pivotal role in LFA-1-dependent T Cell Migration.
ZAP-70 is protein tyrosine kinase of the Syk family that is localized exclusively to the cytosol of T cells and natural killer cells. It is required for T cell activation. It is activated by Lck-mediated phosphorylation of its tyrosine residues.
Physical form
Solution in 25 mM HEPES, pH 7.5, containing 150 mM NaCl, 0.5 mM DTT, and 50% glycerol.
Other Notes
One unit will phosphorylate 1 nmol polyglutamic acid:tyrosine per min at 37 °C at pH 7.0.

Specifications

General

UNSPSC Code	12352200
NACRES	NA.32
MDL number	MFCD03459122
recombinant	expressed in baculovirus infected insect cells (Histidine tagged)
assay	≥90% (SDS-PAGE)
form	buffered aqueous glycerol solution
specific activity	≥150 U/mg
mol wt	70 kDa
UniProt accession no.	P43403
shipped in	dry ice
storage temp.	−70°C
Quality Level	200
Gene Information	human ... ZAP70(7535)

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