Description
Infectious disease is a perennially important area for both life science research and drug discovery. Some of the first applications of IVIS® imaging technology were in tracking infections and monitoring host responses, and these applications are still at the forefront of research.
Our bioluminescent infectious disease light-producing microorganisms have been developed to mimic both acute and chronic standard infection protocols presently used by researchers.
Engineered Bacterium: Staphylococcus aureus - Xen29
Parental Strain: American Type Culture Collection, used under license
In Vitro/Ex Vivo: Growth profiles, Antibiogram, Catheter model
In Vivo: Sepsis, Soft tissue, and Biofilm models
Advantages of using bioluminescent light-producing microorganisms for drug discovery in vitro:
Rapid and readily amenable to high throughput screening, e.g., 96 or 384-well format
Sensitivity - subtle changes in cellular viability are rapidly detected
Inexpensive - no additional substrates needed for bacterial assays
Advantages of using bioluminescent light-producing microorganisms for drug discovery in vivo:
Rapid identification of lead drug candidates
Real-time efficacy data
May help to decrease drug failure by allowing disease relapse to be monitored in the same animal
