Revvity, NEV10640, IVISense Integrin Receptor 645 Fluorescent Probe (IntegriSense)

IVISense Integrin Receptor 645 fluorescent imaging probe for in vivo detection of αvβ3 integrin is a low molecular weight peptidomimetic antagonist coupled to a red fluorochrome. This validated, high affinity (Kd = 4.2 nM) fluorescent probe has improved circulation half-life and specificity over RDG peptide-based agents, with selectivity 5-20x for αvβ3 integrin, for precise detection of αvβ3 integrins. This integrin-targeted molecular imaging probe enables non-invasive imaging to better understand biological processes, and disease biology and progression. Including IVISense Integrin Receptor 645 fluorescent agent in careful experimental design allows for multiplexing with other channels and/or imaging times, and can be paired with other probes to achieve maximum efficiency and flexibility in your imaging studies.