Description
The PATfix®AAV Switcher Platform streamlines upstream AAV analysis by enabling direct characterization of crude harvest without pre-purification or multiple orthogonal assays. Using a dual-column, valve-switch workflow, it performs cation exchange capture step followed by high-resolution chromatographic separation in a single run, supported by UV, FLD and MALS detection. This integrated approach provides consistent separations and delivers quantitative readouts such as percentage of full capsids alongside impurity profiles.By reducing manual handling, the platform minimizes variability and error risk while shortening time-to-decision for process development and MSAT teams. User-friendly, 21 CFR Part 11–compliant software supports secure data management, tailored analysis, audit trails, and collaborative result sharing. Together, these capabilities help optimize upstream conditions, monitor process consistency, and control analytical complexity and cost, providing a path to improved AAV productivity.
