Description
MEP HyperCel is a flexible mixed mode chromatography resin designed for capture and purification of antibodies and various recombinant proteins from laboratory to manufacturing scale. MEP HyperCel resin offers a no salt/low salt alternative to conventional HIC and can simplify processes and improve economics by removing the need for salt addition and following UF/DF steps. The MEP ligand is immunoglobulin-selective. Thus, MEP Hypercel can be effectively used for IgG capture and for enhanced DNA, HCP and aggregate removal. Elution is under mild conditions.
MEP HyperCel pre-packed columns are designed to simplify resin screening and selection, making them ideal for optimizing process steps. The RoboColumn®format is particularly suited for high throughput process development (HTPD), allowing for efficient and streamlined purification processes. Features and Benefits Unique separation mechanism and differentiated selectivity
Direct protein capture from a variety of feedstocks
No salt addition required for binding means a simpler process, lower costs and reduced waste
Stable toward harsh cleaning with NaOH Applications A no-salt/low-salt alternative to Hydrophobic Interaction Chromatography (HIC)
Monoclonal and polyclonal IgG capture and intermediate purification (aggregate, DNA and HCP removal)
Direct capture of recombinant proteins or enzymes from feedstock without need for pH or conductivity adjustments
