Wako, 012-27683, Anti Phosphorylated Tau S422, Monoclonal Antibody(AP422)

This product is for research use only. Do not administer it to human. Tau is one of the microtubule-associated proteins, which is mainly expressed in neurons of the central nervous system, and controls the stabilization of microtubules., In the brains of Alzheimer's disease patients, it is reported that neurofibrillary tangle accumulated by phosphorylated Tau is formed, and the extent of its appearance correlates with the severity of dementia. Therefore, Tau is being studied for investigating the cause of Alzheimer's disease and developing therapeutic drugs. This product is mouse monoclonal antibody which recognizes phosphorylated Tau at S422., [Antigen] human Tau 417-427 a.a. phosphorylated S422 (CGGIDMVDpSPQLAT), [Antibody subclass] mouse IgG1 kappa, [Species cross reactivity] human, mouse, [Experimental adaptation] Western blot (1:1,000), immunohistochemical staining (1:1,000), [Reference], 1)Hasegawa, M., et al.: FEBS Lett., 384, 1, 25(1996)., 2)Goedert, M., et al.: FEBS Lett., 409, 1, 57(1997)., 3)Buee-Scherrer, V., et al.: FEBS Lett., 515, 1, 151(2002)., 4)Delobel, P., et al., J. Neurochem., 83, 2, 412(2002)., 5)Bellucci, A., et al.: Am. J. Pathol., 165, 5, 1643(2004)., 6)Sylvie, L. C., et al.: PNAS, 103, 25, 9673(2006)., 7)Schindowski, K., et al.: Am. J. Pathol., 169, 2, 599(2006)., 8)Audouard, E., et al.: Am. J. Pathol., 186, 10, 2709(2016).