Wako, 015-26953, Anti Human Tau, Rat Monoclonal Antibody(RTM49)

This product is for research use only. Do not administer it to human., Tau is one of microtubule-associated proteins, mainly expressed in the central nervous system neurons, and it adjusts the stabilization of microtubules. In the brains of Alzheimer's disease patients, it is reported that neurofibrillary tangles are caused by accumulation of phosphorylated Tau, and the extent of its appearance correlates with the severity of dementia. Therefore, Tau is studied for investigating the cause of Alzheimer's disease and developing therapeutic drugs., This product is a rat monoclonal antibody which recognizes human Tau. It recognizes all Tau regardless of phosphorylation modification or isoform., [Antigen] human Tau full length recombinant, [Epitope] Tau 2-44a.a., [Antibody subclass] rat IgG1kappa, [Species cross-reactivity] human *no reaction to mouse and rat Tau, [Laboratory indication] Western blot, immunohistochemistry, Immunocytochemistry, [Reference], 1) Kubo, A., et al.: J. Comp. Neurol., 527, 985 (2019)., 2) Kubo, A., et al.: J. Neurosci., 39, 34, 6781(2019).