Wako, 018-26742, A-83-01, MF

"This product is for research use only. Do not administer it to human.This is registered in Master File., A-83-01 is a selective inhibitor of TGF-β type I / activin receptor-like kinase (ALK5), type I activin / nodal receptor-like kinase (ALK4) / type I nodal receptor-like kinase (ALK7) . It inhibits phosphorylation of Smad2/3 and induced epithelial mesenchymal transition TGF-β. This product has little or no effect on osteogenic factor type I receptor, p38 MAP kinase and extracellular regulated kinase. In addition, it has been reported that rat iPS cells can be grown uniformly without differentiation and can be cultured for a long time by adding to rat's iPS cell culture medium., [Li, W., et al.:, Cell Stem Cell, ,, 4, , 16(2009).]