Wako, 161-21442, Palladium-Activated Carbon Ethylenediamine Complex (Pd 3.5～6.5%)

This product is for research use only. Do not administer it to human., Palladium-Activated Carbon Ethylenediamine Complex, (Pd 5%) [Pd/C (en)], 5% Pd/C (en) is a heterogeneous catalyst, whose structure is a 1:1 complex of the Pd/C, s Pd and ethylenediamine. It enables a selective catalytic reduction of various functional groups under neutral conditions. It can be readily removed by filtration after the reaction.5% Pd/C (en) is an excellent reduction catalyst that is not combustible, unlike the general Pd/C, and has good storage stability.The development into industrial scale is anticipated.In the catalytic reductions using 5% Pd/C (en), it is possible to easily reduce various functional groups, including olefin, azido, nitro, benzyl ester, aromatic halogen, etc., while inhibiting the reduction of protectinggroups, such as benzyl ether, 1), , CBI (benzyloxycarbonyl) group, 1), 2), which is an aliphatic amine, O-TBDMS (t-butyldimethylsilyl) group, 3), , epoxide, 5), and benzyl alcohol, 5), ., [References], H. Sajiki, K. Hattori, K. Hirota :, J. Org. Chem.,, 63, , 7990 (1998)., K. Hattori, H. Sajiki, K. Hirota :, Tetrahedron, ,, 56, , 8433 (2000)., K. Hattori, H. Sajiki, K. Hirota :, Tetrahedron Lett., ,, 41, , 5711 (2000)., H. Sajiki, K. Hattori, K. Hirota :, Chem. Eur. J., ,, 6, , 2200 (2000)., H. Sajiki, K. Hattori, K. Hirota :, J. Chem Soc., Perkin Trans, ., 1, , 4043 (1998).