Cytiva Lipid Nanoparticle (LNP) Instruments & Reagents Collection

With Cytiva’s lipid nanoparticle (LNP) formulation solutions, you benefit from advanced microfluidic mixing technology that delivers precise control over particle size and encapsulation efficiency. This ensures consistent RNA delivery and reproducible results, no matter the scale.

Cytiva’s NanoAssemblr platforms—including Spark and Ignite—are designed for scalable LNP production, supporting your workflow from research to GMP manufacturing. By using pre-optimized GenVoy-ILM reagents, you streamline formulation and achieve high-quality, reliable outcomes for applications in mRNA vaccines, gene therapy, and beyond.

Key Applications of Lipid Nanoparticle (LNP) Delivery

Lipid nanoparticle (LNP) technology is transforming the field of nucleic acid therapeutics, enabling you to deliver mRNA, siRNA, and other RNA molecules with enhanced stability and efficiency. By using Cytiva’s LNP formulation platforms, you can accelerate research and development across a broad spectrum of biomedical applications, from preclinical studies to clinical manufacturing.

You can leverage LNP delivery for:

mRNA vaccine development: Achieve efficient encapsulation and delivery for next-generation vaccines, including COVID-19 and emerging infectious diseases.

Gene therapy: Support safe and effective delivery of genetic material for gene editing and rare disease treatment.

RNA therapeutics: Advance siRNA, saRNA, and antisense oligonucleotide therapies for targeted gene silencing or modulation.

Preclinical and clinical research: Facilitate reproducible LNP formulation and scale-up for seamless transition from laboratory discovery to clinical trials.

How to Select the Right Cytiva LNP Formulation System

Choosing the optimal Cytiva LNP formulation system helps you efficiently scale your workflow from early research through to clinical production. Whether you’re working with microgram or milliliter volumes, Cytiva offers flexible solutions—including the NanoAssemblr Spark, Ignite, and specialized LNP kits—to match your project’s requirements.

Selecting your LNP system:

• NanoAssemblr Spark: Ideal for discovery and R&D, enabling precise lipid nanoparticle formulation at the microgram (µg) scale.

• NanoAssemblr Ignite: Designed for process development and preclinical studies, supporting scalable LNP production at the milliliter (mL) scale.
• NxGen Cartridges: Disposable, microfluidic cartridges compatible with Spark and Ignite systems, ensuring consistent mixing and easy workflow integration.
• GenVoy-ILM and RNA Delivery LNP Kits: Pre-optimized reagent kits for high-efficiency RNA encapsulation across various applications and volumes.

By matching your sample volume and application needs, you can streamline lipid nanoparticle formulation and accelerate progress from lab research to GMP manufacturing.

Cytiva LNP Formulation Instruments and Reagents

Cytiva offers a comprehensive lineup of lipid nanoparticle formulation instruments and reagents to meet the needs of every stage in your workflow—from early discovery to large-scale production. Each solution is designed to maximize reproducibility, efficiency, and flexibility for mRNA, RNA, and gene therapy applications.

Key Products:

• NanoAssemblr Spark:
  A compact, user-friendly microfluidic system for rapid LNP formulation at the microgram scale. Ideal for discovery and early research.
• NanoAssemblr Ignite:
  Scalable instrument designed for process development and preclinical production. Delivers precise, reproducible LNP formulation at the milliliter scale.
• NanoAssemblr Blaze:
  High-throughput system engineered for large-volume and GMP manufacturing, supporting seamless scale-up of your LNP workflow.
• NxGen Microfluidic Cartridges:
  Disposable cartridges compatible with Spark and Ignite systems, ensuring consistent microfluidic mixing and minimizing cross-contamination.
• GenVoy‑ILM Reagents:
  Pre-optimized lipid mixtures for high-efficiency RNA encapsulation, supporting reliable results from research through clinical development.
• RNA Delivery LNP Kit:
  Comprehensive kit with all necessary reagents for rapid screening, optimization, and validation of RNA-LNP formulations.

These solutions enable you to streamline lipid nanoparticle preparation, improve encapsulation efficiency, and maintain quality from research to clinical manufacturing.

LNP Formulation FAQs: Choosing Systems, RNA Types, and Scaling Up

1. How do I select the right Cytiva LNP formulation system for my project?

The best system depends on your application scale and workflow needs. NanoAssemblr Spark is perfect for microgram-scale research and screening, while Ignite offers higher throughput at the milliliter scale for process development. For GMP and clinical manufacturing, Blaze supports large-volume, compliant production. All systems use NxGen cartridges for reproducible microfluidic mixing and seamless scale-up

2. How scalable are Cytiva’s LNP formulation systems?

The NanoAssemblr portfolio is designed for true process scalability. You can start with Spark for R&D, transition to Ignite for preclinical batches, and move to Blaze for clinical and GMP manufacturing—all while maintaining consistent LNP quality and performance.

3. Are Cytiva LNP workflows compatible with GMP production requirements?

Yes, the NanoAssemblr Blaze and associated reagents support GMP-compliant workflows, helping you meet regulatory standards for clinical and commercial RNA-based therapeutics.