Thermo Fisher Chromatography Syringes for GC & HPLC

These precision syringes deliver micro- to milliliter-scale injections for GC, GC-MS, LC, and HPLC workflows. On this Collection page, you can quickly shortlist by application, seal type, volume, needle design, and autosampler model—then buy directly from Iright’s Thermo Fisher portfolio.

How to Choose the Right GC/HPLC Syringe

The right match depends on solvent strength, matrix volatility, injection volume, and instrument interface. Start with your method, then narrow by seal type (gas-tight vs liquid-tight), needle configuration (fixed vs RN), tip style, and autosampler compatibility to minimize carryover and downtime. 

Quick guidance (for copy, not specs):

Application first: Manual GC, GC autosampler, HPLC loop loading, or headspace GC (higher temperature/pressure demands).

Seal type: Gas-tight (PTFE-sealed) favors volatile/organic matrices and GC; liquid-tight/microliter syringes suit LC/HPLC loading. 

Needle style: Fixed needles minimize dead volume; the RN (removable needle) eases gauge/tip swaps, as well as maintenance.

Autosampler fit: Choose syringes validated for TriPlus™ RSH, AI/AS 1310, or AS1000/AS3000/AS3500 families.

Sub-Collections & Use Cases: GC, HPLC, Headspace, Autosamplers

To speed up selection, we’ve grouped Thermo Fisher syringes by task. Use these as entry points, then filter by volume, gauge, length, and tip.

• Manual GC Syringes — Hand injections and method development where tactility matters. 
  
• GC Autosampler Syringes (TriPlus™ RSH/SMART, AI/AS) — Fixed or RN needles; some SMART versions embed an ID chip for part/lot tracking.
  

• HPLC/LC Syringes — Loop loading and LC autosampler use, with square tips and robust borosilicate builds.
  
• Headspace/High-temp GC Syringes — Select models rated for the method’s temperature and septum-piercing duty cycle (see compatible families below).

Comparison & Spec Matrix: Volume, Needle, Tip, Compatibility

Before you add to cart, compare the most-requested models below. Always confirm final specs on the product page.

Catalog No.	Application	Volume	Needle	Gauge/Length	Key Notes	For Use With
365B0511	Manual GC	1 µL	Plunger-in-needle, fixed	23 G, 50 mm	Borosilicate barrel; stainless plunger/needle; cone tip	Manual/GC autosampler (per product page)
365I2351	GC autosampler	250 µL	Fixed GT needle	23 G, 57 mm	Fixed-needle GT design for TriPlus RSH	TriPlus™ RSH
365D0331	GC autosampler	10 µL	Fixed GT needle	26s G	Small-volume precise injections	TriPlus™ RSH
365H2161	GC autosampler	100 µL	Fixed GT needle	26s G	Field-proven RSH family design	TriPlus™ RSH
365A0241-SM	GC autosampler	(various)	SMART (ID-chip)	—	Tracks part/lot/usage history for compliance	TriPlus™ RSH SMART
365L2321-SM	GC autosampler	(various)	SMART (ID-chip)	—	Same as above; SMART lineup variant	TriPlus™ RSH SMART
365ILT91	HPLC autosampler	250 µL	Liquid-tight	—	Square tip, robust markings	AS1000/AS3000
365JLT61	HPLC autosampler	500 µL	Liquid-tight	—	Borosilicate + stainless; reproducible injections	AS1000/AS3000
365LLT81	HPLC autosampler	2.5 mL	Liquid-tight	—	Larger volume for extended sequences	AS3000/AS3500

Autosampler Compatibility & Spares (TriPlus, AI/AS, AS-Series)

Autosamplers are model-specific; pairing the correct syringe reduces errors and rework. Use this glance map, then confirm the exact spec on the product page.

• TriPlus™ RSH / RSH SMART → Fixed-needle and SMART syringes (with optional ID chip) for traceability and compliance. Popular: 365I2351 (250 µL fixed GT), plus SMART variants such as 365A0241-SM / 365L2321-SM.

• AI/AS 1310 → Liquid GC autosampler platform with syringe thermal stability and cross-contamination-free rinsing; check its user guide/specs when choosing volume/needle.

• AS1000 / AS3000 / AS3500 (HPLC) → Use Thermo Scientific HPLC syringes validated for each platform; common picks include 365ILT91 (250 µL) and 365JLT61 (500 µL) for AS1000/AS3000, and 365LLT81 (2.5 mL) for AS3000/AS3500. 

Common spares & related items: RN needles, plunger/seal kits (where applicable), GC septa and liners, autosampler vials/caps, and HPLC vials. Stock these alongside syringes to maintain uptime.

Use, Care & Carryover Control for GC/HPLC Syringes

Good technique keeps instruments stable and peaks consistent. The practices below help new users switch volumes or matrices confidently while protecting septa and valves.

• Pre-condition & rinse with your method solvent before loading; avoid air bubbles and memory effects.
• Inspect tips and seals regularly; clean immediately after high-salt or strong acid/alkali matrices.
• Mind temperature limits for headspace and high-temp GC; follow the syringe’s rated max temperature.
  
• Keep motions consistent: Insertion depth, plunger speed, and dwell time influence peak shape and reproducibility.
• Protect storage: Use tip guards; replace bent or blunted needles to prevent septum damage.

Popular Picks: Best-Selling Thermo Fisher Syringes

Use these cards to jump straight to trusted choices. Each links to full specs and compatibility.

365I2351 — TriPlus™ RSH Fixed GT Syringe, 250 µL, 23 G
Chosen for reliable GC autosampler injections and robust build (borosilicate barrel, stainless needle/plunger). Ideal for routine sequences on RSH.

365ILT91 — HPLC Syringe, 250 µL
Square-tip, easy-read markings, validated for AS1000/AS3000; a balanced volume for everyday loop loading.

365JLT61 — HPLC Syringe, 500 µL
A higher-volume option for longer runs or larger loop volumes on AS1000/AS3000 autosamplers.

365LLT81 — HPLC Syringe, 2.5 mL
Favored on AS3000/AS3500 when larger load volumes or extended batch capacity are required.

365A0241-SM/365L2321-SM — TriPlus™ RSH SMART Syringes
Embedded ID chip tracks part/lot/usage history for audit-friendly traceability and data confidence.

FAQs: Gas-Tight vs Liquid-Tight, RN vs Fixed, Tip Styles

A concise answer bank for what users actually search—also marked up with FAQPage schema on publish.

Q1. Gas-tight vs liquid-tight—how should I pick?
Choose gas-tight for volatile/organic-rich GC work where PTFE sealing helps, and liquid-tight/microliter for LC loop loading; then size to your method’s volume.

Q2. Fixed needle or RN (removable needle)?
Fixed needles minimize dead volume and potential leak paths; RN designs make it easy to swap gauge/length or replace a damaged tip—useful in methods that vary matrices.

Q3. What about SMART syringes?
For TriPlus™ RSH SMART, selected syringes include an ID chip to log part/lot and usage—useful for compliance, training labs, and GxP settings.

Q4. Which HPLC syringes fit AS-series autosamplers?
Common matches include 365ILT91 (250 µL) and 365JLT61 (500 µL) for AS1000/AS3000, and 365LLT81 (2.5 mL) for AS3000/AS3500. Always confirm on the product page.

Q5. Do AI/AS 1310 GC autosamplers require special syringes?
They support a range of GC syringes and parameters; consult the AI/AS 1310 specifications/user guide when selecting volume and tip.

Q6. How do tip styles affect injections?
Cone/bevel/tapered tips influence septum piercing and dead volume. Follow the instrument/method recommendation and keep the tip in good condition to protect peak shape.

Talk to Iright

Need help matching a syringe to TriPlus™ RSH, AI/AS 1310, or AS-series? Tell us your method, solvent, loop volume, and autosampler model. Iright sources a broad Thermo Fisher range and can bundle vials, caps, GC septa/liners, and spare needles so your team gets a plug-and-run kit.