Description
Key facts
CAS number:587871-26-9,
Purity:>99%,
Form:SolidSee storage information,
Molecular weight:395.5 Da,
Molecular formula:C21H17NO3S2,
PubChem:5278396,
Nature:Synthetic,
Solubility:Soluble in DMSO to 100 mMSoluble in ethanol to 50 mM,
Biochemical name:2-Morpholino-6-(thianthren-1-yl)-4H-pyran-4-one,
Biological description:Potent, selective and competitive ATM kinase inhibitor. IC50 values are 12.9 (ATM), 2000 (DNA-PK), 9300 (mTOR), 16600 (PI3K), >100000 (ATR) and >100000 nM (PI4K). Sensitizes cells to ionizing radiation and chemotherapeutics. Blocks Akt phosphorylation, induces G1 cell cycle arrest and induces apoptosis in breast and prostate cell lines.,
Canonical smiles:C1COCCN1C2=CC(=O)C=C(O2)C3=C4C(=CC=C3)SC5=CC=CC=C5S4,
InChi:InChI=1S/C21H17NO3S2/c23-14-12-16(25-20(13-14)22-8-10-24-11-9-22)15-4-3-7-19-21(15)27-18-6-2-1-5-17(18)26-19/h1-7,12-13H,8-11H2,
InChiKey:XRKYMMUGXMWDAO-UHFFFAOYSA-N,
IUPAC Name:2-morpholin-4-yl-6-thianthren-1-ylpyran-4-one
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
