Description
Key facts
CAS number:1947-37-1,
Purity:>98%,
Form:SolidSee storage information,
Molecular weight:596.7 Da,
Molecular formula:C29H36N6O6S,
PubChem:446569,
Nature:Synthetic,
Solubility:Soluble in DMSO to 1 mg/ml,
Biochemical name:Tetragastrin,
Canonical smiles:CSCCC(C(=O)NC(CC(=O)O)C(=O)NC(CC1=CC=CC=C1)C(=O)N)NC(=O)C(CC2=CNC3=CC=CC=C32)N,
Isomeric smiles:CSCC[C@@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N)NC(=O)[C@H](CC2=CNC3=CC=CC=C32)N,
InChi:InChI=1S/C29H36N6O6S/c1-42-12-11-22(33-27(39)20(30)14-18-16-32-21-10-6-5-9-19(18)21)28(40)35-24(15-25(36)37)29(41)34-23(26(31)38)13-17-7-3-2-4-8-17/h2-10,16,20,22-24,32H,11-15,30H2,1H3,(H2,31,38)(H,33,39)(H,34,41)(H,35,40)(H,36,37)/t20-,22-,23-,24-/m0/s1,
InChiKey:RGYLYUZOGHTBRF-BIHRQFPBSA-N,
IUPAC Name:(3S)-3-[[(2S)-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-4-methylsulfanylbutanoyl]amino]-4-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-4-oxobutanoic acid
Properties and Storage Information:
Shipped at conditions-Ambient - Can Ship with Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Storage information-Store under desiccating conditions, The product can be stored for up to 12 months
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
The CCK2-R also known as CCK-B receptor or Cholecystokinin B receptor and its counterpart CCK1-R (commonly referred to as CCK-A) are G-protein-coupled receptors involved in various physiological processes. The CCK-B receptor has a molecular mass of approximately 50 kDa. It is mainly expressed in the brain particularly in areas like the cerebral cortex and hypothalamus. These receptors also appear in peripheral tissues like the stomach and pancreas. Their primary role involves binding with peptides like gastrin and cholecystokinin (CCK) after which they trigger intracellular signaling pathways.
Biological function summary
CCK-B and CCK-A receptors mediate important processes like gastric acid secretion anxiety modulation and satiety. CCK-B receptor specifically often forms a part of receptor-ligand complexes that influence signaling cascades in neurons. The receptors interact with CCK peptides that act as CCK agonists contributing to various digestive and behavioral responses. These interactions allow the regulation of hormone release and food intake making them important modulators of gastrointestinal functions and neurological responses.
Pathways
CCK-B and CCK-A receptors integrate deeply within the gastrin-Ca2+ signaling pathway and phospholipase C (PLC) signaling. The gastrin-Ca2+ pathway significantly impacts gastric acid secretion and digestive enzyme release. Phospholipase C activation leads to inositol trisphosphate production which increases intracellular Ca2+ levels influencing cellular responses. In these pathways CCK receptors interact with proteins such as phospholipase C and IP3 receptors ensuring proper signaling and physiological outcomes.
CCK-B receptors are implicated in conditions like anxiety disorders and gastrointestinal diseases like gastric ulcers. The altered expression or dysfunction of CCK-B receptors influences anxiety levels and stress responses. Moreover in gastric ulcers disruptions in the normal signaling of these receptors can affect gastric acid secretion and mucosal protection. Through these diseases associations with proteins such as corticotropin-releasing factor and gastrin illustrate the receptors' roles in the pathophysiology of stress-related disorders and gastrointestinal tract dysfunctions.
