Description
Product details
Patented technology Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMAb® patents.
How are conjugated primary antibodies validated? This conjugated primary antibody is released using a quantitative quality control method that evaluates binding affinity post-conjugation and efficiency of antibody labeling. For suitable applications and species reactivity, please refer to the unconjugated version of this clone.
What are the advantages of a recombinant monoclonal antibody? This product is a recombinant monoclonal antibody, which offers several advantages including:
- High batch-to-batch consistency and reproducibility
- Improved sensitivity and specificity
- Long-term security of supply
- Animal-free batch production
For more information, read more on recombinant antibodies.
Supplementary information
This supplementary information is collated from multiple sources and compiled automatically.
Biological function summary
Bok plays an important role in the intrinsic apoptosis pathway by modulating mitochondrial outer membrane permeabilization. Bok forms protein complexes with other Bcl-2 family members like Bax and Bak contributing to cytochrome c release. This release is important for the activation of caspases leading to cellular apoptosis. Bok also exercises a regulatory role on calcium homeostasis within cells although its exact mechanisms remain under study.
Pathways
Bok integrates into the mitochondrial apoptosis pathway and the endoplasmic reticulum stress response influencing cellular fate decisions. Within these pathways Bok interacts with proteins such as Bax Bak and Bcl-2 balancing pro-apoptotic and anti-apoptotic signals. Bok's ability to influence these pathways demonstrates its importance in maintaining cellular homeostasis and response to stress signals.