Description
Key facts
Purity:>95% SDS-PAGE,
Expression system:Native,
Tags:Tag free,
Applications:FuncS, SDS-PAGESee reactivity dataSee the reactivity data table below for information on validated species and application combinations.,
Biologically active:Yes,
Biological activity:Active,
Accession:P08514,
Animal free:No,
Carrier free:No,
Species:Human,
Storage buffer:pH: 7.4Preservative: 0.05% Sodium azideConstituents: 50% Glycerol (glycerin, glycerine), 0.58% Sodium chloride, 0.316% Tris HCl, 0.1% Triton X-100, 0.0111% Calcium chloride
Product details:
Extinction coefficient: 0.91
Protein concentration determined via the Bradford method.
Host species: Human.
REACH authorisation
Abcam has not and does not intend to apply for the REACH Authorisation of customers' uses of products that contain European Authorisation list (Annex XIV) substances.
It is the responsibility of our customers to check the necessity of application of REACH Authorisation, and any other relevant authorisations, for their intended uses.
Properties and Storage Information:
Shipped at conditions-Blue Ice, Appropriate short-term storage conditions--20°C, Appropriate long-term storage conditions--20°C, Aliquoting information-Upon delivery aliquot, Storage information-Avoid freeze / thaw cycle
Supplementary Information:
This supplementary information is collated from multiple sources and compiled automatically.
Integrin alpha 2b + beta 3 also known as glycoprotein IIb/IIIa is an important heterodimeric integrin protein complex essential for platelet adhesion and aggregation. This integrin with a mass around 210 kDa functions as a receptor for fibrinogen and other adhesive proteins. Expression of integrin alpha 2b beta 3 is found mainly in platelets and megakaryocytes. The integrin protein's alpha 2b subunit contributes to its specificity and is involved in binding to the ligand while the beta 3 subunit influences activation and signal transduction.
Biological function summary
Integrin alpha 2b beta 3 plays a major role in hemostasis by mediating platelet cohesion and clot formation at sites of vascular injury. This integrin is an important part of the platelet glycoprotein complex that forms a bridge to link platelets through fibrinogen. Through its function integrin alpha 2b beta 3 is responsible for ensuring the stability of clots in blood vessels preventing loss of blood. It also interacts with various signaling molecules inside platelets facilitating processes like shape change and granule secretion.
Pathways
Integrin alpha 2b beta 3 involvement in hemostatic pathways reveals its importance in thrombocytopenic mechanisms. Inside the platelet signaling pathways such as phosphatidylinositol 3-kinase (PI3K) and Src family kinases become activated upon ligand binding to this integrin. These pathways involve other proteins like talin and kindlin which play roles in integrin inside-out activation. Additionally crosstalk with other integrins reinforces platelet adhesion and spreading.
Integrin alpha 2b beta 3 associations with thrombotic disorders highlight its clinical significance. Its dysregulation can lead to conditions such as myocardial infarction and stroke where excessive platelet aggregation causes vascular blockages. The integrin also connects to disorders like Glanzmann's thrombasthenia a condition resulting from mutations in the integrin alpha 2b or beta 3 subunits leading to impaired clot formation. The integrin protein's interaction with fibrinogen and von Willebrand factor further emphasizes its impact on thrombotic diseases.
