Bio-Rad, 6600-5906, Neisseria Meningitidis antibody

Rabbit anti Neisseria meningitidis antibody reacts with Neisseria meningitidis serogroups A, B and C recognizing multiple antigens. Other serogroups have not been tested. N. meningitidis is a gram-negative bacteria that is a causative agent of meningitis. There are 13 known significant serogroups, classified according to the structure of their polysaccharide capsule. Serogroups, A, B, C, D, X, Y, Z, 29E and W135 are responsible for virtually all cases of the human disease. The carbohydrate component of the capsular membrane induces a T cell independent immune response, so neither long term immunity by memory cell formation nor antibody affinity maturation is observed. Rather than being engulfed and processed by an antigen presenting cell, the carbohydrate capsule interacts directly with B cells. This interaction causes production of serogroup specific antibodies, primarily IgM. IgG is also produced with an IgG1 response predominating in children and an IgG2 response predominating in adults.

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.