Bio-Rad, 7049-5020, Orexin A antibody

Sheep anti Human orexin A antibody recognizes the human orexin A subunit of orexin, also known as hypocretin. Orexin is cleaved into Orexin A, also known as hypocretin-1, a 32 amino acid excitatory neuropeptide linked to alertness and wakefulness in humans. Orexin A binds to both orexin receptors 1 and 2 with similar affinity whilst orexin B corresponding to the C terminal region of the holopeptide binds only to the orexin receptor 2. Mutations in the orexin gene can lead to the development of Narcolepsy 1 ( NRCLP1 ), a condition characterized by sleep fragmentation and daytime drowziness, abnormal REM sleep and sleep paralysis along with other sleep related symptoms ( Peyron et al. 2000 ). Sheep anti Human orexin A antibody is a useful reagent for immunohistochemistry on formalin fixed, paraffin embedded tissue sections.

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.