Bio-Rad, AAM36, IL-4 antibody

Rabbit anti Mouse Interleukin-4 antibody recognizes mouse interleukin-4 (IL-4), also known as B-cell stimulatory factor 1, a 120 amino acid pleiotropic cytokine cleaved from a 140 amino acid precursor which interacts with multiple cell lineages, including T cells, fibroblasts and macrophages ( Crawford et al. 1987 ). Interleukin-4 is one of the most important factors involved in B cell IgG1 and IgE class switching ( Winter et al. 1987 ). IL-4 acts as a regulator of low affinity Fc receptor for IgE (CD23) expression on both lymphocytes and monocytes ( Miyajima et al. 1991 , Hudak et al. 1987 ). IL-4 acts through binding to it's cognate receptor CD124, a receptor which also binds the related cytokine IL-13. Interleukin -4 plays an important role in the alternative activation of murine macrophages as indicated by the ability to potently up-regulate the expression and activity of CD206, the macrophage mannose receptor ( Stein et al. 1992 ).

Storage Information
This product is shipped at ambient temperature.
Prior to reconstitution store at -20°C.
After reconstitution store at -20°C.
This product should be stored undiluted. Storage in frost-free freezers is not recommended. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.