Bio-Rad, AHP1821, IL-23 Receptor antibody

Goat anti Human Interleukin-23 receptor antibody recognizes the human interleukin-23 receptor (IL-23R). The interleukin-23 receptor is 629 amino acid ~72kDa single pass type I transmembrane glycoprotein belonging to the type I cytokine receptor family and possessing two fibronectin type III domains. Multiple potential isoforms formed by alternative splicing are described. Goat anti Human Interleukin-23 receptor antibody recognizes an epitope within the N-terminal (NT) region of Interleukin-23 receptor (IL-23R), present in isoforms 1, 3 and 4 ( UniProt: Q5VWK5 ), the antibody is not expected to recognize other truncated forms of the receptor lacking the immunogen sequence. IL-23R is a mediator of T-cell, NK cell, and possibly macrophage/myeloid cell, stimulation acting as the receptor for IL-23, by association with the beta component of IL-12R and is thought to signal through activation of the JAK-STAT signaling pathway. Genetic variation in IL23R is associated with inflammatory bowel disease type 17 ( Kistner et al. 2006 ) and susceptibility to the ulcerative and inflammatory psoriasis ( Hüffmeier et al. 2009 ). Goat anti Human Interleukin-23 receptor antibody is reported as suitable for use in immunocytochemistry on acetone fixed cells and has been used successfully for the immunohistochemical localization of IL-23R in formalin fixed, paraffin embedded human tissues. .

Storage Information
This product is shipped at ambient temperature. It is recommended to aliquot and store at -20°C on receipt. When thawed, aliquot the sample as needed. Keep aliquots at 2-8°C for short term use (up to 4 weeks) and store the remaining aliquots at -20°C.
Avoid repeated freezing and thawing as this may denature the antibody. Storage in frost-free freezers is not recommended.