Bio-Rad, AHP3001, SMPD1 antibody

Rabbit anti SMPD1 antibody recognizes sphingomyelin phosphodiesterase, also known as ASM, Sphingomyelin Phosphodiesterase, ASMASE and NPD. It is a lipid hydrolase that converts sphingomyelin to the bioactive messenger ceramide, and is activated by a number of molecules including TNF-alpha and LPS (Rozanova et al. 2010). Mutations in the SMPD1 gene resulting in deficient ASM production cause Niemann-Pick disease, one type of which causes lethality within three years of life (Schuchman 2007). SMPD1 mutations have also been implicated in sporadic Parkinson's disease (Mao et al. 2017). A role of ASM on mood regulation has been suggested, with high ASM expression implicated in major depressive episodes (Gulbins et al. 2015).

Storage Information
This product is shipped at ambient temperature.
Store at -20°C
Storage in frost-free freezers is not recommended.
This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.